Genetic polymorphisms in VDR, ESR1 and ESR2 genes may contribute to susceptibility to Parkinson’s disease: a meta-analysis

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• 作者：Zhan Gao (1)
  Hong-Juan Fu (1)
  Ju-Jun Xue (1)
  Zhi-Xuan Wu (1)
  Li-Bo Zhao (1)
  
• 关键词：VDR ; ESR1 ; ESR2 ; Parkinson’s disease ; Meta ; analysis
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：41
• 期：7
• 页码：4463-4474
• 全文大小：550 KB
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• 作者单位：Zhan Gao (1)
  Hong-Juan Fu (1)
  Ju-Jun Xue (1)
  Zhi-Xuan Wu (1)
  Li-Bo Zhao (1)
  
  1. Department of Elderly Neurology, Heilongjiang Hospital, Zhongshan Road No. 82, Xiangfang District, Harbin, 150000, People’s Republic of China
  
• ISSN：1573-4978

文摘

We conducted this meta-analysis of relevant case–control studies to investigate the relationships between genetic polymorphisms in VDR, ESR1 and ESR2 genes to the susceptibility of Parkinson’s disease (PD). A search on electronic databases without any language restrictions was conducted: MEDLINE (1966-013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-013), CINAHL (1982-013), Web of Science (1945-013) and the Chinese Biomedical Database (1982-013). Meta-analysis was performed using the STATA statistical software. Crude odds ratio (OR) with their 95?% confidence interval (95?% CI) was calculated. Fourteen case–control studies with a total of 3,689 PD patients and 4,627 healthy subjects were included in our meta-analysis. The results of our meta-analysis demonstrated that the VDR genetic polymorphisms might be closely related to increased risks of PD (allele model: OR?=?1.18, 95?% CI 1.09-.29, P?P?ESR1 genetic polymorphisms might increase the risk of PD (allele model: OR?=?1.56, 95?% CI 1.17-.07, P?=?0.002; recessive model: OR?=?1.93, 95?% CI 1.33-.80, P?P?=?0.038; heterozygous model: OR?=?2.04, 95?% CI 1.36-.07, P?=?0.001; respectively), especially for the polymorphisms rs2234693 and rs9340799. Furthermore, we found significant correlations of ESR2 genetic polymorphisms with the risk of PD (allele model: OR?=?1.78, 95?% CI 1.19-.67, P?=?0.005; recessive model: OR?=?1.93, 95?% CI 1.15-.27, P?=?0.014; homozygous model: OR?=?1.77, 95?% CI 1.09-.89, P?=?0.022; heterozygous model: OR?=?1.88, 95?% CI 1.08-.27, P?=?0.025; respectively), especially for the rs1256049 polymorphism. Our meta-analysis suggests that genetic polymorphisms in VDR, ESR1 and ESR2 genes may contribute to increased risks for PD.