Transplacental Transfer of Polychlorinated Biphenyls, Polybrominated Diphenylethers, and Organochlorine Pesticides in Ringed Seals (Pusa hispida)

详细信息    查看全文

• 作者：T. M. Brown ; P. S. Ross ; K. J. Reimer
• 刊名：Archives of Environmental Contamination and Toxicology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：70
• 期：1
• 页码：20-27
• 全文大小：668 KB
• 参考文献：Addison RF, Brodie PF (1977) Organochlorine residues in materinal blubber, milk, pup blubber from grey seals (Halichoerus grypus) from Sable Island, Nova Scotia. J Fish Res Board Can 34:937–941CrossRef
  Addison RF, Brodie PF (1987) Transfer of organochlorine residues from blubber through the circulatory system to milk in the lactating gray seal (Halichoerus grypus). Can J Fish Aquat Sci 44:782–786CrossRef
  Aguilar A, Borrell A (1994) Reproductive transfer and variation of body load of organochlorine pollutants with age in fin whales (Balaenoptera physalus). Arch Environ Contam Toxicol 27:546–554CrossRef
  Ando M, Saito H, Wakisaka I (1985) Transfer of polychlorinated biphenyls (PCBs) to newborn infants through the placenta and mother’s milk. Arch Environ Contam Toxicol 14:51–57CrossRef
  Boon JP, van Arnhem E, Jansen S, Kannan N, Petrick G, Schulz D et al (1992) The toxicokinetics of PCBs in marine mammals with species reference to possible interactions of individual congeners with the cytochorme P450-dependent monooxygenase system. In: Walker CH, Livingstone D (eds) An overview persistant pollutants in marine ecosystems. Elsevier, Oxford, pp 119–159CrossRef
  Borrell A, Anguilar A (2005) Mother-calf transfer of organochlorine compounds in the common dolphin (Delphinus delphis). Bull Environ Contam Toxicol 75:149–156CrossRef
  Braekevelt E, Tittlemier SA, Tomy GT (2003) Direct measurement of octanol–water partition coefficients of some environmentally relevant brominated diphenyl ether congeners. Chemosphere 51:563–567CrossRef
  Brown TM, Fisk AT, Helbing CC, Reimer KJ (2014a) PCB profiles in ringed seals (Pusa hispida) reveal historical contamination by a military radar station in Labrador, Canada. Environ Toxicol Chem 33:592–601CrossRef
  Brown TM, Ross PS, Reimer KJ et al (2014b) PCB related effects threholds as derived through gene transcript profiles in locally contaminated ringed seals (Pusa hispida). Environ Sci Toxicol 48:12952–12961
  Debier C, Pomeroy PP, Dupont C et al (2003) Quantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus. Mar Ecol Prog Ser 247:237–248CrossRef
  Desforges JW, Ross PS, Loseto LL (2012) Transplacental transfer of polychlorinated biphenyls and polybrominated diphenyl ethers in Arctic Beluga whales (Delphinapterus leucas). Environ Toxicol Chem 31:296–300CrossRef
  Donkin P, Mann SV, Hamilton EI (1981) Polychlorinated biphenyl, DDT and dieldrin residues in grey seal (Halichoerus grypus) males, females and mother-feotus pairs sampled at the Farne Islands, England, during the breeding season. Sci Total Environ 19:121–142CrossRef
  Gaden A, Ferguson SH, Harwood L, Melling H, Alikamik J, Stern GA (2012) Western Canadian Arctic ringed seal organic contaminant trends in relation to sea ice break-up. Environ Sci Technol 46:4427–4433CrossRef
  Gauger KJ, Kato Y, Haraguchi K et al (2004) Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal brain but do not bind to thyroid hormone receptors. Environ Health Perspect 112:516–523CrossRef
  Greig DJ, Ylitalo GM, Hall AJ, Fauquier DA, Gulland FMD (2007) Transplacental transfer of organochlorines in California sea lions (Zalophus californianus). Environ Toxicol Chem 26:37–44CrossRef
  Hammill MO (1987) Ecology of the ringed seal (Phoca hispida Schreber) in the fast-ice of Barrow Strait. Macdonald College of McGill University, Sainte-Anne-de-Bellevue
  Hawker DW, Connell DW (1988) Octanol–water partition coefficients of polychlorinated biphenyl congeners. Environ Sci Technol 22:382–387CrossRef
  Helle E, Olsson M, Jensen S (1976a) DDT and PCB levels and reproduction in ringed seals from the Bothnian Bay. Ambio 5:188–189
  Helle E, Olsson M, Jensen S (1976b) High frequencies of pathological changes in seal uteri correlated with PCB levels. Ambio 5:261–263
  Ikonomou MG, Fraser T, Crewe N, Fischer MB, Rogers IH, He T (2001) A comprehensive multiresidue ultra-trace analytical method, based on HRGC/HRMS, for the determination of PCDDs, PCDFs, PCBs, PBDEs, PCDEs, and organochlorine pesticides in six different environmental matrices. Can Tech Rep Fish Aquat Sci 2389:1–95
  Jacobson JL, Jacobson SW (2002) Association of prenatal exposure to an environmental contaminant with intellectual function in childhood. J Toxicol Clin Toxicol 40:467–475CrossRef
  Lyderson C (1995) Energetics of pregnancy, lactation and neonatal development in ringed seals (Phoca hispida). In: Blix AS, Walløe L, Ulltang Ø (eds) Developments in marine biology 4: Whales, seals, fish and man. Elsevier, Amsterdam, pp 319–327
  Mackay D, Shiu WY, Ma KC (1992) Illustrated handbook of physical–chemical properties and environmental fate for organic chemicals. Lewis, Boca Raton
  Mos L, Tabuchi M, Dangerfield N, Jeffries SJ, Koop BF, Ross PS (2007) Contaminant-associated disruption of vitamin A and its receptor (RARα) in free ranging harbour seals (Phoca vitulina). Aquat Toxicol 81:319–328CrossRef
  Mos L, Cameron M, Jeffries SJ, Koop BF, Ross PS (2010) Risk-based analysis of polychlorinated biphenyl toxicity in harbor seals. Integr Environ Assess Manag 6:631–640CrossRef
  Muir D, Riget F, Cleeman M et al (2000) Circumpolar trends of PCBs and organochlorine pesticides in the arctic marine environment inferred from levels in ringed seals. Environ Sci Technol 34(12):2431–2438CrossRef
  Nyman M, Bergknut M, Fant ML et al (2003) Contaminant exposure and effects in Baltic ringed and grey seals as assessed by biomarkers. Mar Environ Res 55:73–99CrossRef
  Pomeroy PP, Green N, Hall AJ, Walton M, Jones K, Harwood J (1996) Congener-specific exposure of grey seal (Halichoerus grypus) pups to chlorinated biphenyls during lactation. Can J Fish Aquat Sci 53:1526–1534
  Ross PS, De Swart RL, Timmerman HH et al (1996) Contaminant-related immunosuppression in harbor seals fed herring from the Baltic Sea. Fundam Appl Toxicol 30:136
  Ross PS, Ellis GM, Ikonomou MG, Barrett-Lennard LG, Addison RF (2000) High PCB concentrations in free-ranging pacific killer whales, Orcinus orca: effects of age, sex and dietary preferences. Mar Pollut Bull 40:504–515CrossRef
  Ross PS, Jeffries SJ, Yunker MB, Addison RF, Ikonomou MG, Calambokidis JC (2004) Harbor seals (Phoca vitulina) in British Columbia, Canada, and Washington State, USA, reveal a combination of local and global polychlorinated biphenyl, dioxin, and furan signals. Environ Toxicol Chem 23(1):157–165CrossRef
  Routti H, Arukwe A, Jenssen BM et al (2010) Comparative endocrine disruptive effects of contaminants in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea. Comp Biochem Physiol 152:306–312
  Ryg M, Lydersen C, Markussen NH (1990) Estimating the blubber content of phocid seals. Can J Fish Aquat Sci 47:1223–1227CrossRef
  Siddiqui MK, Srivastava S, Srivastava SP, Mehrotra PK, Mathur N, Tandon I (2003) Persistent chlorinated pesticides and intrauterine fetal growth retardation: a possible association. Int Arch Occup Environ Health 76:75–80
  Smith TG (1987) The ringed seal, Phoca hispida, of the Canadian Western Arctic. Can Bull Fish Aqu Sci 216:81
  Sormo EG, Skaare JU, Lydersen C, Kovacs KM, Hammill MO, Jensen BM (2003) Partitioning of persistent organic pollutants in grey seal (Halichoerus grypus) mother-pup pairs. Sci Total Environ 302:145–155CrossRef
  Stewart REA, Stewart BE, Stirling I, Street E (1996) Counts of growth layer groups in cementum and dentine in ringed seals (Phoca hispida). Mar Mamm Sci 12:383–401CrossRef
  Tanabe S, Tatsukawa R, Maruyama K, Miyazaki N (1982) Transplacental transfer of PCBs and chlorinated pesticides from the pregnant striped dolphin (Stenella coeruleoalba) to her fetus. Agric Biol Chem 46:1249–1254CrossRef
  Wang D, Atkinson S, Hoover-Miller A, Shelver WL, Li QX (2012) Organic halogenated contaminants in mother–fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000-2002. J Hazard Mater 223–224:72–78
  Wolkers H, Burkow IC, Hammill MO, Lydersen C, Witkamp RF (2002) Transfer of polychlorinated biphenyls and chlorinated pesticides from mother to pup in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the Gulf of St. Lawrence. Can Environ Toxicol Chem 21:94–101CrossRef
  Wolkers H, Lydersen C, Kovacs KM (2004) Accumulation and lacatational transfer of PCBs and pesticides in harbor seals (Phoca vitulina) from Svalbard, Norway. Sci Total Environ 319:137–146CrossRef
  
• 作者单位：T. M. Brown (1) (2)
  P. S. Ross (3)
  K. J. Reimer (4)
  
  1. Raincoast Conservation Foundation, P.O. Box 2429, Sidney, BC, V8L 3Y3, Canada
  2. Memorial University of Newfoundland, St. John’s, NL, A1B 3X9, Canada
  3. Ocean Pollution Research Program, Vancouver Aquarium Marine Science Center, P.O. Box 3232, Vancouver, BC, V6B 3X8, Canada
  4. Environmental Sciences Group, Royal Military College of Canada, P.O. Box 17000, Stn Forces, Kingston, ON, K7K 7B4, Canada
  
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment
  Terrestrial Pollution
  Agriculture
  Ecology
  Forestry
  Environment
  Soil Science and Conservation
  
• 出版者：Springer New York
• ISSN：1432-0703

文摘

The transplacental transfer of persistent organic pollutants in marine mammals takes place at a formative developmental period, thereby exposing the fetus to endocrine-disrupting compounds. We evaluated the transplacental transfer of polychlorinated biphenyls (PCBs), polybrominated diphenylethers (PBDEs), and organochlorine pesticides (OCPs) in five pregnant ringed seals in Northern Labrador, Canada. PCBs, PBDEs, and OCPs were transferred from the mother to the fetus with average concentrations in the fetuses ranging from 0.3 ng/g lipid weight (lw) of mirex to 94 ng/g lw of PCBs. The average percent transferred to the blubber in the fetus was very low with <0.02 % for each of the compounds studied. Based on relationships observed, transfer for full-term fetuses is estimated to range from 0.03 to 0.27 %. Log K _ow explained the transfer of PCBs (r 2 = 0.67, p < 0.001) and OCPs (r 2 = 0.62, p < 0.001) with those PCB congeners and OCP compounds having a log K _ow of <6.0 and 4.6, respectively, because they are preferentially transferred to the fetus. Adult females transferred a contaminant mixture to their fetuses, which correlated with estimated fetal age (p < 0.001; r 2 = 0.697), with younger fetuses showing a greater proportion of compounds with low K _ow compared with later-term fetuses. The implications for the prenatal exposure to these developmental toxicants remains unknown because current toxicity thresholds in marine mammals have only been derived from juveniles or adults.