On the use of propensity scores in case of rare exposure
详细信息 查看全文
- 作者：David Hajage ; Florence Tubach ; Philippe Gabriel Steg…
- 关键词：Propensity scores ; Observational studies ; Pharmacoepidemiology ; Rare exposure ; Hazard ratio ; Monte Carlo simulations
- 刊名：BMC Medical Research Methodology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：2,599 KB
- 刊物主题：Theory of Medicine/Bioethics; Statistical Theory and Methods; Statistics for Life Sciences, Medicine, Health Sciences;
- 出版者：BioMed Central
- ISSN：1471-2288
文摘
Background Observational post-marketing assessment studies often involve evaluating the effect of a rare treatment on a time-to-event outcome, through the estimation of a marginal hazard ratio. Propensity score (PS) methods are the most used methods to estimate marginal effect of an exposure in observational studies. However there is paucity of data concerning their performance in a context of low prevalence of exposure.