Segmental hair analysis and estimation of methamphetamine use pattern

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• 作者：Eunyoung Han (1)
  Heejin Yang (1)
  Ilung Seol (1)
  Yunshin Park (1)
  Bongwoo Lee (1)
  Joon Myong Song (2)
  
• 关键词：Segmental hair analysis ; Methamphetamine users ; Methamphetamine use history ; Methamphetamine use patterns
• 刊名：International Journal of Legal Medicine
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：127
• 期：2
• 页码：405-411
• 全文大小：342KB
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• 作者单位：Eunyoung Han (1)
  Heejin Yang (1)
  Ilung Seol (1)
  Yunshin Park (1)
  Bongwoo Lee (1)
  Joon Myong Song (2)
  
  1. National Forensic Service, 111, Daedeok-ri, Seosam-myeon, Jangseong-gun, Jeollanam-do, 515-822, South Korea
  2. Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea
  
• ISSN：1437-1596

文摘

The aim of this study was to investigate whether the results of segmental hair analysis can be used to estimate patterns of methamphetamine (MA) use. Segmental hair analysis for MA and amphetamine (AP) was performed. Hair was cut into the hair root, consecutive 1?cm length segments and 1-?cm length segments. Whole hair was also analyzed. The hair samples were incubated for 20?h in 1?mL methanol containing 1?% hydrochloric acid after washing the hair samples. Hair extracts were evaporated and derivatization was performed using trifluoroacetic anhydride in ethylacetate at 65?°C for 30?min. Derivatized extract was analyzed by gas chromatography/mass spectrometry. The 15 subjects consisted of 13 males and two females and their ages ranged from 25 to 42 (mean, 32). MA and AP concentrations in the whole hair ranged from 3.00 to 105.10?ng/mg (mean, 34.53) and from 0.05 to 4.76?ng/mg (mean, 2.42), respectively. Based on the analysis of the 1?cm length segmental hair, the results were interpreted in a way to distinguish between continuous use of MA (n--0), no recent but previous use of MA (n--), and recent but no previous use of MA (n--). Furthermore, the individuals were interpreted as light, moderate, and heavy users based on concentration ranges previously published.