Evaluation of different periods of estrogen replacement onset in the tibia of ovariectomized rats

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• 作者：Marianne Spalding…
• 关键词：Hormone replacement therapy ; Estrogen ; Postmenopausal bone loss ; Ovariectomy
• 刊名：Aging Clinical and Experimental Research
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：26
• 期：5
• 页码：465-471
• 全文大小：884 KB
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• 作者单位：Marianne Spalding (1) (2)
  Priscila Ferreira Amschlinger (1)
  Luana Marotta Reis de Vasconcellos (1)
  Gabriela de Morais Gouvêa Lima (1)
  Warley David Kerbauy (3)
  Ivan Balducci (4)
  Yasmin Rodarte Carvalho (1)
  
  1. Department of Bioscience and Oral Diagnosis-Dentistry School, Univ Estadual Paulista “Júlio de Mesquita Filho- Campus of S?o José dos Campos, S?o José dos Campos, SP, Brazil
  2. Av Francisco José Longo, 777, Jd. S?o Dimas, 12245-000, S?o José dos Campos, SP, Brazil
  3. Department of Diagnosis and Surgery-Dentistry School, Univ Estadual Paulista “Júlio de Mesquita Filho- Campus of S?o José dos Campos, S?o José dos Campos, SP, Brazil
  4. Department of Community Dentistry and Pediatric Clinic-Dentistry School, Univ Estadual Paulista “Júlio de Mesquita Filho- Campus of S?o José dos Campos, S?o José dos Campos, SP, Brazil
  
• ISSN：1720-8319

文摘

Background and aims Estrogen deficiency results in increased bone turnover and can lead to osteoporosis. Hormone replacement therapy (HRT) seems to be the most effective means of reducing bone loss and fractures. However, the effects of the period of HRT onset on bone tissue require further elucidation. This study aimed to evaluate the effects of different periods of HRT onset on the trabecular bone of ovariectomized rats. Methods Seventy-five ovariectomized Wistar rats were divided into five groups according to the onset of treatment. Each group was subdivided into experimental (E; n?=?10) and control (C; n?=?5), according to treatment with 17-β-estradiol or vehicle alone (soybean oil), respectively, administered subcutaneously. The first group received treatment immediately post-surgery, while treatment in the remaining groups was initiated 1, 2, 3 and 4?weeks post-surgery. Euthanasia occurred at 9?weeks post-surgery. The left tibias were removed and prepared for histomorphometric analyses. The histomorphometric results were statistically analyzed by the Student’s t test (p? Results The percentage of trabecular bone was significantly greater in the first (p?=?0.002) and second (p?=?0.039) experimental subgroups compared with the control for the same period. In the experimental subgroups, the percentage of trabecular bone decreased according to the delay in HRT onset and was statistically significant (t?=?3.367; p?=?0.0023). Conclusion These findings indicate an increase in trabecular bone loss in tibia at 9?weeks post-ovariectomy. The period of HRT/E onset is important for preventing bone loss; however, despite its preventive effects, HRT/E does not restore lost bone.