Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration

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• 作者：Rita A. Costa ; João C. R. Cardoso ; Deborah M. Power
• 关键词：Angiopoietin ; like proteins ; Evolution ; Expression ; Skin regeneration ; Teleost
• 刊名：BMC Evolutionary Biology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：2543KB
• 刊物主题：Evolutionary Biology; Animal Systematics/Taxonomy/ Biogeography; Entomology; Genetics and Population Dynamics; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2148
• 卷排序：17

文摘

BackgroundThe skin in vertebrates is a protective barrier and damage is rapidly repaired to re-establish barrier function and maintain internal homeostasis. The angiopoietin-like (ANGPTL) proteins are a family of eight secreted glycoproteins with an important role in skin repair and angiogenesis in humans. In other vertebrates their existence and role in skin remains largely unstudied. The present study characterizes for the first time the homologues of human ANGPTLs in fish and identifies the candidates that share a conserved role in skin repair using a regenerating teleost skin model over a 4-day healing period.