The contribution of Alu exons to the human proteome

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• 作者：Lan Lin ; Peng Jiang ; Juw Won Park ; Jinkai Wang ; Zhi-xiang Lu…
• 关键词：Alu ; Transposable element ; Exon ; Alternative splicing ; RNA editing ; RNA ; seq ; Ribo ; seq ; Transcriptome ; Proteome ; Evolution ; Primate
• 刊名：Genome Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,190 KB
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• 作者单位：Lan Lin (1)
  Peng Jiang (2)
  Juw Won Park (1) (3) (4)
  Jinkai Wang (1)
  Zhi-xiang Lu (1)
  Maggie P. Y. Lam (5)
  Peipei Ping (5) (6)
  Yi Xing (1)
  
  1. Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA
  2. Regenerative Biology, Morgridge Institute for Research, Madison, WI, 53707, USA
  3. Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY, 40292, USA
  4. KBRIN Bioinformatics Core, University of Louisville, Louisville, KY, 40202, USA
  5. Department of Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA
  6. Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA
  
• 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Microbial Genetics and Genomics; Fungus Genetics; Bioinformatics;
• 出版者：BioMed Central
• ISSN：1465-6906

文摘

Background Alu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial. The prevailing view is that exons derived from young repetitive elements, such as Alu elements, are restricted to regulatory functions and have not had adequate evolutionary time to be incorporated into stable, functional proteins.