The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine
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- 作者：Alireza Majdi ; Javad Mahmoudi ; Saeed Sadigh-Eteghad…
- 关键词：Ischemic stroke ; Glutamate excitotoxicity ; MicroRNA ; NMDA receptors ; AMPA receptors
- 刊名：Neurological Sciences
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：37
- 期：11
- 页码：1765-1771
- 全文大小：403 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Neurology
Neuroradiology
Neurosurgery
Psychiatry - 出版者：Springer Milan
- ISSN：1590-3478
- 卷排序：37
文摘
Stroke is the second leading cause of death and the most common cause of adult disabilities among elderlies. It involves a complex series of mechanisms among which, excitotoxicity is of great importance. Also, miRNAs appear to play role in post-stroke excitotoxicity, and changes in their transcriptome occur right after cerebral ischemia. Recent data indicate that specific miRNAs such as miRNA-223, miRNA-181, miRNA-125a, miRNA-125b, miRNA-1000, miRNA-132 and miRNA-124a regulate glutamate neurotransmission and excitotoxicity during stroke. However, limitations such as poor in vivo stability, side effects and inappropriate biodistribution in miRNA-based therapies still exist and should be overcome before clinical application. Thence, investigation of the effect of application of these miRNAs after the onset of ischemia is a pivotal step for manipulating these miRNAs in clinical use. Given this, present review concentrates on miRNAs roles in post-ischemic stroke excitotoxicity.