Clonorchis sinensis excretory/secretory products promote the secretion of TNF-alpha in the mouse intrahepatic biliary epithelial cells via Toll-like receptor 4
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- 作者：Chao Yan ; Yan-Hong Wang ; Qian Yu ; Xiao-Dan Cheng ; Bei-Bei Zhang…
- 关键词：Toll ; like receptor 4 ; Clonorchis sinensis ; Biliary epithelial cells ; Excretory/secretory products ; Interleukin (IL) ; 6 ; Tumor necrosis factor (TNF) ; α
- 刊名：Parasites & Vectors
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：1
- 全文大小：2,596 KB
- 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine; Entomology;
- 出版者：BioMed Central
- ISSN：1756-3305
文摘
Background Toll-like receptor 4 (TLR4), as one of the most important pathogen pattern recognitions (PPRs) plays a central role in elicitation of innate immunity and mediation of adaptive responses against foreign antigens. However, little is known of the roles of TLR4 in the immune responses of biliary epithelial cells (BECs) induced by Clonorchis sinensis, a parasite of significance in human health.