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Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists Utilizing Data from the Exenatide Clinical Trial Development Program
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  • 作者：Hui Peng ; Laura L. Want ; Vanita R. Aroda
  • 关键词：GLP ; 1 receptor agonists ; Incretin ; Exenatide ; Safety ; Pancreatitis ; Cardiovascular
  • 刊名：Current Diabetes Reports
  • 出版年：2016
  • 出版时间：May 2016
  • 年：2016
  • 卷：16
  • 期：5
  • 全文大小：387 KB
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  • 作者单位：Hui Peng (1) (2) (3)
    Laura L. Want (1)
    Vanita R. Aroda (1) (3)

    1. MedStar Health Research Institute, 6562 Belcrest Rd, Suite 700, Hyattsville, MD, 20782, USA
    2. MedStar Washington Hospital Center, Washington, DC, USA
    3. Georgetown University School of Medicine, Washington, DC, USA
  • 刊物主题：Diabetes;
  • 出版者：Springer US
  • ISSN：1539-0829
    • 文摘
    Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated benefits for patients with type 2 diabetes including A1C reduction and weight loss with minimal risk of hypoglycemia. This article provides an evidence-based update of safety and tolerability considerations for the clinical use of GLP-1RAs as a class, with a specific detailed review of data from the exenatide clinical trial development program, which has the longest history and availability of safety and tolerability data as the first-approved GLP-1RA. Specific areas covered include comparative risk of hypoglycemia, as well as pancreatic, thyroid, and cardiovascular safety data; clinical guidance regarding current safety and tolerability data is also reviewed.

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