How cardiomyocytes sense pathophysiological stresses for cardiac remodeling

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• 作者：Zaffar K. Haque ; Da-Zhi Wang
• 关键词：Cardiomyopathy ; Heart failure ; Signaling pathway ; Transcription ; MicroRNAs ; Gene expression
• 刊名：Cellular and Molecular Life Sciences
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：74
• 期：6
• 页码：983-1000
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Cell Biology; Biomedicine, general; Life Sciences, general; Biochemistry, general;
• 出版者：Springer International Publishing
• ISSN：1420-9071
• 卷排序：74

文摘

In the past decades, the cardiovascular community has laid out the fundamental signaling cascades that become awry in the cardiomyocyte during the process of pathologic cardiac remodeling. These pathways are initiated at the cell membrane and work their way to the nucleus to mediate gene expression. Complexity is multiplied as the cardiomyocyte is subjected to cross talk with other cells as well as a barrage of extracellular stimuli and mechanical stresses. In this review, we summarize the signaling cascades that play key roles in cardiac function and then we proceed to describe emerging concepts of how the cardiomyocyte senses the mechanical and environmental stimuli to transition to the deleterious genetic program that defines pathologic cardiac remodeling. As a highlighting example of these processes, we illustrate the transition from a compensated hypertrophied myocardium to a decompensated failing myocardium, which is clinically manifested as decompensated heart failure.