Efficacy of a topical suspension of bacterial antigens for the management of chronic suppurative otitis media

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• 作者：Renzo Mora (1) renzomora@libero.it
  Francesco Antonio Salzano (2)
  Enzo Mora (1)
  Luca Guastini (1)
• 关键词：Antibiotic resistance &#8211 ; Bacterial antigens &#8211 ; Chronic suppurative otitis media &#8211 ; Lantigen B
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：269
• 期：6
• 页码：1593-1597
• 全文大小：261.8 KB
• 参考文献：1. Verhoeff M, van der Veen EL, Rovers MM, Sanders EA, Schilder AG (2006) Chronic suppurative otitis media: a review. Int J Pediatr Otorhinolaryngol 70:1–12
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• 作者单位：1. ENT Department, University of Genoa, Via dei Mille 11/9, 16147 Genoa, Italy2. ENT Department, University of Palermo, Palermo, Italy
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Otorhinolaryngology
  Neurosurgery
  Head and Neck Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1434-4726

文摘

The aim of this study was to compare the efficacy and safety of a topical suspension of bacterial antigens for the management of chronic suppurative otitis media (CSOM). Two-hundred ten patients with CSOM were enrolled in this study. The patients were divided into two numerically equal groups and randomized to receive a topical suspension of bacterial antigens, Lantigen B (group A), or placebo (group B), according to the following protocol: 5 drops thrice a day for 12 consecutive weeks in the external acoustic duct. The topical suspension of bacterial antigens and placebo were administered by identical, anonymous dispensers in order to maintain double-blind conditions. Before, at the end and 3 months, and after the end of the treatment, all patients who entered in the study underwent pure tone audiometry, microscopic examination of ears, microbiological examination of the ear swab, aural suctioning and subjective assessment of symptoms by visual analog scale. In group A, we saw a statistically significant improvement in the different items measured. A topical suspension of bacterial antigens was significantly more effective than placebo in the treatment of CSOM.