Analysis of EPR and FISH studies of radiation doses in persons who lived in the upper reaches of the Techa River

详细信息    查看全文

• 作者：M. O. Degteva ; N. B. Shagina ; E. A. Shishkina…
• 关键词：Dose reconstruction ; Environmental contamination ; Techa River ; Electron paramagnetic resonance ; Fluorescence in situ hybridization
• 刊名：Radiation and Environmental Biophysics
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：54
• 期：4
• 页码：433-444
• 全文大小：717 KB
• 参考文献：Apostoaei AI, Nair SK, Thomas BA, Lewis CJ, Hoffman FO, Thiessen KM (2000) External exposure to radionuclides accumulated in shoreline sediments with an application to the lower Clinch River. Health Phys 78:700-10CrossRef
  Bauchinger M, Salassidis K, Braselmann H, Vozilova A, Pressl S, Stephan G, Snigiryova G, Kozheurov VP, Akleyev A (1998) FISH-based analysis of stable translocations in a Techa River population. Int J Radiat Biol 73:605-12CrossRef
  Borysheva N, Ivannikov A, Tikunov D, Orlenko S, Skvortsov V, Stepanenko V, Hoshi M (2007) Taking into account absorbed doses in tooth enamel due to internal irradiation of human body by radioactive cesium isotopes at analysis EPR dosimetry data: calculation by Monte-Carlo method. Radiat Meas 42:1190-195CrossRef
  Degteva MO, Vorobiova MI, Kozheurov VP, Tolstykh EI, Anspaugh LR, Napier BA (2000a) Dose reconstruction system for the exposed population living along the Techa River. Health Phys 78:542-54CrossRef
  Degteva MO, Kozheurov VP, Tolstykh EI, Vorobiova MI, Anspaugh LR, Napier BA, Kovtun AN (2000b) The Techa River dosimetry system: methods for the reconstruction of internal dose. Health Phys 79:24-5CrossRef
  Degteva MO, Anspaugh LR, Akleyev AV, Jacob P, Ivanov DV, Weiser A, Vorobiova MI, Shishkina EA, Shved VA, Vozilova AV, Bayankin SN, Napier B (2005) Electron paramagnetic resonance and fluorescence in situ hybridization-based investigations of individual doses for persons living at Metlino in the upper reaches of the Techa River. Health Phys 88:139-53CrossRef
  Degteva MO, Vorobiova MI, Tolstykh EI, Shagina NB, Shishkina EA, Anspaugh LR, Napier BA, Bougrov NG, Shved VA, Tokareva EE (2006) Development of an improved dose reconstruction system for the Techa River population affected by the operation of the Mayak Production Association. Radiat Res 166:255-70CrossRef
  Degteva MO, Tolstykh EI, Vorobiova MI, Shagina NB, Kozyrev AV, Anspaugh LR, Napier BA (2009) Structure of the revised Techa River dosimetry system: exposure pathways and system databases. Urals Research Center for Radiation Medicine and University of Utah, Chelyabinsk and Salt Lake City
  Degteva MO, Shagina NB, Vorobiova MI, Anspaugh LR, Napier BA (2012) Reevaluation of waterborne releases of radioactive materials from the Mayak Production Association into the Techa River in 1949-951. Health Phys 102:25-8CrossRef
  Eckerman KF, Ryman JC (1993) External exposure to radionuclides in air, water, and soil. U.S. Environmental Protection Agency; Federal guidance report No. 12, EPA 402-R-93-081, Washington
  Edwards AA, Lindholm C, Darroudi F, Stefan G, Romm H, Barquinero J, Barrious L, Caballin MR, Roy L, Whitehouse CA, Tawn EJ, Moquet J, Lloyd DC, Voisin P (2005) Review of translocations detected by FISH for retrospective biological dosimetry applications. Radiat Prot Dosimetry 113:395-02CrossRef
  Fattibene P, Callens F (2010) EPR dosimetry with tooth enamel: a review. Appl Radiat Isot 68:2033-116CrossRef
  G?ksu HY, Semiochkina N, Shishkina EA, Wieser A, El-Faramawy NA, Degteva MO, Jacob P, Ivanov DV (2002) Thin layer α-Al2O3: C beta dosemeters for the assessment of current dose rate in teeth due to 90Sr intake, and comparison with electron paramagnetic resonance dosimetry. Radiat Prot Dosimetry 101:507-13CrossRef
  IAEA (2011) Cytogenetic dosimetry: applications in preparedness for and response to radiation emergences. International Atomic Energy Agency, Vienna
  Kozheurov VP (1994) SICH-9.1-A unique whole-body counting system for measuring Sr-90 via bremsstrahlung: the main results from a long-term investigation of the Techa River population. Sci Total Environ 14(1-):37-8CrossRef
  Krestinina LYu, Preston DL, Ostroumova EV, Degteva MO, Ron E, Vyushkova OV, Startsev NV, Kossenko MM, Akleyev AV (2005) Protracted radiation exposure and cancer mortality in the Techa River Cohort. Radiat Res 164:602-11CrossRef
  Napier BA, Shagina NB, Degteva MO, Tolstykh EI, Vorobiova MI, Anspaugh LR (2001) Preliminary uncertainty analysis for the doses estimated using the Techa River dosimetry system-2000. Health Phys 81:395-05CrossRef
  Napier BA, Degteva MO, Shagina NB, Anspaugh LR (2013) Uncertainty analysis for the Techa River dosimetry system. Med Radiol Radiat Saf 58:5-8 (in English and Russian)
  NRC (1995) Radiation dose reconstruction for epidemiologic uses. National Research Council, Washington
  Preston DL, Krestinina LY, Sokolnikov ME, Ron E, Davis FG, Ostroumova EV, Gilbert ES (2010) How much can we say about site-specific cancer radiation risks? Radiat Res 174:816-24CrossRef
  Romanyukha AA, Degteva MO, Kozheurov VP, Wieser A, Jacob P, Ignatiev EA, Vorobiova MI (1996) Pilot study of the Urals population by tooth electron paramagnetic resonance dosimetry. Radiat Environ Biophys 35:305-10CrossRef
  Schonfeld SJ, Krestinina EY, Epifanova SB, Degteva MO, Akleyev AV, Preston DL (2013) Solid cancer mortality in the Techa River Cohort (1950-007). R
• 作者单位：M. O. Degteva (1)
  N. B. Shagina (1)
  E. A. Shishkina (1)
  A. V. Vozilova (1)
  A. Y. Volchkova (1)
  M. I. Vorobiova (1)
  A. Wieser (2)
  P. Fattibene (3)
  S. Della Monaca (3)
  E. Ainsbury (4)
  J. Moquet (4)
  L. R. Anspaugh (5)
  B. A. Napier (6)
  
  1. Urals Research Center for Radiation Medicine, 68a Vorovsky Street, Chelyabinsk, Russian Federation, 454076
  2. Helmholtz Centrum Munich, Neuherberg, Germany
  3. Instituto Superiore di Sanita, Rome, Italy
  4. Public Health England, Chilton, Didcot, UK
  5. University of Utah, Salt Lake City, UT, USA
  6. Pacific Northwest National Laboratory, Richland, WA, USA
  
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Biophysics and Biomedical Physics
  Effects of Radiation and Radiation Protection
  Environmental Physics
  Environmental Computing and Modeling
  Ecosystems
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2099

文摘

Waterborne radioactive releases into the Techa River from the Mayak Production Association in Russia during 1949-956 resulted in significant doses to about 30,000 persons who lived in downstream settlements. The residents were exposed to internal and external radiation. Two methods for reconstruction of the external dose are considered in this paper, electron paramagnetic resonance (EPR) measurements of teeth, and fluorescence in situ hybridization (FISH) measurements of chromosome translocations in circulating lymphocytes. The main issue in the application of the EPR and FISH methods for reconstruction of the external dose for the Techa Riverside residents was strontium radioisotopes incorporated in teeth and bones that act as a source of confounding local exposures. In order to estimate and subtract doses from incorporated 89,90Sr, the EPR and FISH assays were supported by measurements of 90Sr-body burdens and estimates of 90Sr concentrations in dental tissues by the luminescence method. The resulting dose estimates derived from EPR to FISH measurements for residents of the upper Techa River were found to be consistent: The mean values vary from 510 to 550 mGy for the villages located close to the site of radioactive release to 130-60 mGy for the more distant villages. The upper bound of individual estimates for both methods is equal to 2.2-.3 Gy. The EPR- and FISH-based dose estimates were compared with the doses calculated for the donors using the most recent Techa River Dosimetry System (TRDS). The TRDS external dose assessments are based on the data on contamination of the Techa River floodplain, simulation of air kerma above the contaminated soil, age-dependent lifestyles and individual residence histories. For correct comparison, TRDS-based doses were calculated from two sources: external exposure from the contaminated environment and internal exposure from 137Cs incorporated in donors-soft tissues. It is shown here that the TRDS-based absorbed doses in tooth enamel and muscle are in agreement with EPR- and FISH-based estimates within uncertainty bounds. Basically, this agreement between the estimates has confirmed the validity of external doses calculated with the TRDS. Keywords Dose reconstruction Environmental contamination Techa River Electron paramagnetic resonance Fluorescence in situ hybridization