ESWT and alendronate sodium demonstrate equal protective effects in osteoarthritis of the knee

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• 作者：Ching-Jen Wang ; Wen-Yi Chou ; Shan-Ling Hsu ; Chien-Yiu Huang ; Jai-Hong Cheng
• 关键词：Extracorporeal shock wave ; Alendronate ; Osteoarthritis ; Knee ; Rat
• 刊名：Shock Waves
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：26
• 期：1
• 页码：53-62
• 全文大小：1,579 KB
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• 作者单位：Ching-Jen Wang (1) (2)
  Wen-Yi Chou (1) (2)
  Shan-Ling Hsu (1) (2)
  Chien-Yiu Huang (1)
  Jai-Hong Cheng (1)
  
  1. Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
  2. Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung District, Kaohsiung, 833, Taiwan
  
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Mechanics, Fluids and Thermodynamics
  Fluids
  Thermodynamics
  Acoustics
  Condensed Matter
  Solid State Physics and Spectroscopy
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2153

文摘

This study compared the effects of extracorporeal shock wave therapy (ESWT) and alendronate sodium (alendronate) in osteoarthritis (OA) of rat knees. The control group was subjected to a sham surgery and did not receive either ESWT or alendronate treatment. The OA group underwent anterior cruciate ligament transection (ACLT) and medial meniscectomy (MM) surgery and did not receive either ESWT or alendronate. The ESWT group underwent ACLT and MM surgery and received ESWT after the surgery. The alendronate group received alendronate after ACLT and MM surgery. The evaluations included radiograph, bone mineral density (BMD), serum C-telopeptide collagen II (CTX-II), cartilage oligomeric protein (COMP), alkaline phosphatase and osteocalcin, histopathological examination and immunohistochemical analysis. Radiographs at 12 weeks showed pronounced OA changes in the OA group. The BMD values, CTX-II, COMP, alkaline phosphatase and osteocalcin showed no significant difference between ESWT and alendronate groups. In histopathology, the Mankin and Safranin O scores significantly increased in the OA, ESWT and alendronate groups, but without any significant difference between the ESWT and alendronate groups. In immunohistochemical analysis, the von Willebrand factor (vWF), vascular endothelial factor (VEGF), soluble vascular cell adhesion molecule (sVCAM), proliferating cell nuclear antigen (PCNA), bone morphogenetic protein 2 (BMP-2), and osteocalcin expressions in articular cartilage and subchondral bone showed a significant decrease in the OA group, but no difference was noted between the ESWT and alendronate groups. In conclusion, ESWT and alendronate sodium demonstrate equal protective effects from developing osteoarthritis of the knee in rats. Keywords Extracorporeal shock wave Alendronate Osteoarthritis Knee Rat