Coating with artificial matrices from collagen and sulfated hyaluronan influences the osseointegration of dental implants

详细信息    查看全文

• 作者：Matthias C. Schulz (1)
  Paula Korn (1)
  Bernd Stadlinger (2)
  Ursula Range (3)
  Stephanie M?ller (4)
  Jana Becher (4)
  Matthias Schnabelrauch (4)
  Ronald Mai (1)
  Dieter Scharnweber (5)
  Uwe Eckelt (1)
  Vera Hintze (5)
  
• 刊名：Journal of Materials Science Materials in Medicine
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：25
• 期：1
• 页码：247-258
• 全文大小：650 KB
• 作者单位：Matthias C. Schulz (1)
  Paula Korn (1)
  Bernd Stadlinger (2)
  Ursula Range (3)
  Stephanie M?ller (4)
  Jana Becher (4)
  Matthias Schnabelrauch (4)
  Ronald Mai (1)
  Dieter Scharnweber (5)
  Uwe Eckelt (1)
  Vera Hintze (5)
  
  1. Department of Oral and Maxillofacial Surgery, Medical Faculty “Carl Gustav Carus- Technische Universit?t Dresden, Fetscherstra?e 74, 01307, Dresden, Germany
  2. Clinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, Plattenstr. 11, 8032, Zurich, Switzerland
  3. Institute for Medical Informatics and Biometry, Medical Faculty “Carl Gustav Carus-Technische Universit?t Dresden, Blasewitzer Str. 86, 01309, Dresden, Germany
  4. Biomaterials Department, INNOVENT e.V., Prüssingstrasse 27 B, 07745, Jena, Germany
  5. Institute of Materials Science, Max-Bergmann-Center of Biomaterials, Technische Universit?t Dresden, Budapester Str. 27, 01062, Dresden, Germany
  
• ISSN：1573-4838

文摘

Dental implants are an established therapy for oral rehabilitation. High success rates are achieved in healthy bone, however, these rates decrease in compromised host bone. Coating of dental implants with components of the extracellular matrix is a promising approach to enhance osseointegration in compromised peri-implant bone. Dental titanium implants were coated with an artificial extracellular matrix (aECM) consisting of collagen type I and either one of two regioselectively low sulfated hyaluronan (sHA) derivatives (coll/sHA1Δ6s and coll/sHA1) and compared to commercial pure titanium implants (control). After extraction of the premolar teeth, 36 implants were inserted into the maxilla of 6 miniature pigs (6 implants per maxilla). The healing periods were 4 and 8?weeks, respectively. After animal sacrifice, the samples were evaluated histomorphologically and histomorphometrically. All surface states led to a sufficient implant osseointegration after 4 and 8?weeks. Inflammatory or foreign body reactions could not be observed. After 4?weeks of healing, implants coated with coll/sHA1Δ6s showed the highest bone implant contact (BIC; coll/sHA1Δ6s: 45.4?%; coll/sHA1: 42.2?%; control: 42.3?%). After 8?weeks, a decrease of BIC could be observed for coll/sHA1Δ6s and controls (coll/sHA1Δ6s: 37.3?%; control: 31.7?%). For implants coated with coll/sHA1, the bone implant contact increased (coll/sHA1: 50.8?%). Statistically significant differences could not be observed. Within the limits of the current study, aECM coatings containing low sHA increase peri-implant bone formation around dental implants in maxillary bone compared to controls in the early healing period.