Neurological complications of beta-thalassemia

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• 作者：P. Nemtsas ; M. Arnaoutoglou ; V. Perifanis ; E. Koutsouraki…
• 关键词：Extramedullary hematopoiesis ; Cerebrovascular disease ; Peripheral neuropathy ; Desferrioxamine neurotoxicity
• 刊名：Annals of Hematology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：94
• 期：8
• 页码：1261-1265
• 全文大小：149 KB
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• 作者单位：P. Nemtsas (1)
  M. Arnaoutoglou (1)
  V. Perifanis (2)
  E. Koutsouraki (1)
  A. Orologas (1)
  
  1. First Department of Neurology, University General Hospital of Thessaloniki AHEPA, St.Kiriakidis 1, 546 36, Thessaloniki, Greece
  2. First Propedeutic Department of Internal Medicine, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greece
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584

文摘

The thalassemias are the most common single gene disorder in the world. Over the last years, several reports have demonstrated neurological complications in beta-thalassemia patients. In most cases, these complications remained subclinical and were detected only during neuropsychological, neurophysiological, or neuroimaging evaluation. Cognitive impairment, abnormal findings on evoked potentials, complications due to extramedullary hematopoiesis, cerebrovascular disease, and peripheral neuropathy comprise the broad spectrum of neurological involvement. Chronic hypoxia, iron overload, desferrioxamine neurotoxicity, and bone marrow expansion are implicated, but sufficient explanatory evidence is lacking and development of biomarkers is needed. This review summarizes current knowledge of the neurological complications. As life expectancy for beta-thalassemia patients increases, we support the use of neurophysiological, neuropsychological, or neuroimaging monitoring, enabling the evaluation of neural pathway impairment, to achieve appropriate management and as a result a better quality of life for this patient group.