Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy

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• 作者：Tomoaki Higashiyama ; Yasuhiro Nishida…
• 关键词：Thyroid ; associated ophthalmopathy ; Magnetic resonance imaging ; Extraocular muscle ; Methylprednisolone pulse therapy ; Short TI inversion recovery
• 刊名：Japanese Journal of Ophthalmology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：59
• 期：2
• 页码：124-130
• 全文大小：346 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Japan
• ISSN：1613-2246

文摘

Purpose To quantitatively evaluate the efficacy of methylprednisolone pulse therapy for extraocular muscle inflammation in thyroid-associated ophthalmopathy (TAO) using the short-tau inversion-recovery (STIR) technique of magnetic resonance imaging (MRI). Methods The signal intensities of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured using the STIR images from 34 eyes of 17 patients with TAO before and after methylprednisolone pulse therapy and 19 eyes of 19 controls. The signal intensity ratio (SIR) of the signal intensity in muscles to that in brain white matter was calculated. Results The mean SIRs of the controls were 1.08?±?0.26 in the SR, 1.32?±?0.29 in the IR, 1.34?±?0.19 in the LR, 1.47?±?0.25 in the MR, and 1.28?±?0.22 in the SO muscles. SIRs exceeding 2.0 were out of the normal range. The SIRs of the patients with TAO before treatment were 2.19?±?0.64, 2.44?±?0.58, 1.96?±?0.43, 2.24?±?0.47, and 1.91?±?0.42, respectively, which was significantly (P?P? Conclusion Extraocular muscle inflammation in TAO improved with treatment. However, inflammation in some muscles persisted after treatment, and a high SIR in the muscle after treatment suggested the risk of deterioration of TAO.