A case of suicide by self-injection of adrenaline

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• 作者：Cristian Palmiere ; Fabien Bévalot…
• 关键词：Adrenaline ; Auto ; injector ; Suicide ; Postmortem biochemistry
• 刊名：Forensic Science, Medicine, and Pathology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：11
• 期：3
• 页码：421-426
• 全文大小：349 KB
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• 作者单位：Cristian Palmiere (1)
  Fabien Bévalot (2)
  Daniel Malicier (3)
  Eric Grouzmann (4)
  Tony Fracasso (1)
  Laurent Fanton (3)
  
  1. CURML, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
  2. Laboratoire LAT LUMTOX, Lyon, France
  3. Faculté de Médecine, Institut médico-légal, Lyon, France
  4. Service of Biomedicine, Catecholamine and Peptides Laboratory, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
  
• 刊物主题：Pathology; Forensic Medicine; Criminology & Criminal Justice;
• 出版者：Springer US
• ISSN：1556-2891

文摘

Adrenaline (epinephrine) auto-injectors provide life-saving pre-hospital treatment for individuals experiencing anaphylaxis in a community setting. Errors in handling adrenaline auto-injectors, particularly by children and healthcare professionals, have been reported. Reports of adrenaline overdoses are limited in the medical literature. In most of these cases, accidental adrenaline administration results from medical error. Exogenous administration of catecholamine is responsible for cardiovascular and metabolic responses, which may cause supraventricular tachycardia, ventricular dysrhythmias and myocardial ischemia. The authors present a unique autopsy case involving a 34year-old woman who intentionally self-injected adrenaline using an adrenaline auto-injector as part of a suicide plan. Catecholamines and metanephrines were measured in peripheral and cardiac blood as well as urine and vitreous humor. Based on the results of all postmortem investigations, the cause of death was determined to be cardiac dysrhythmia and cardiac arrest following adrenaline self-injection.