Influence of the watch and wait strategy on clinical outcomes of patients with follicular lymphoma in the rituximab era

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• 作者：Sayako Yuda ; Dai Maruyama ; Akiko Miyagi Maeshima ; Shinichi Makita…
• 关键词：Follicular lymphoma ; Watch and wait ; Time to treatment failure ; Rituximab
• 刊名：Annals of Hematology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：95
• 期：12
• 页码：2017-2022
• 全文大小：330 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Hematology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0584
• 卷排序：95

文摘

We analyzed the effects of the initial approach to patients with follicular lymphoma (FL) on outcomes in order to investigate whether the watch and wait (WW) strategy is still an acceptable approach in the rituximab era. We retrospectively analyzed 348 patients who were initially diagnosed with FL between 2000 and 2012. We compared the clinical outcomes of the WW cohort and immediate treatment cohort. Among 348 patients (median age of 57 years, range: 19–85), 101 were initially managed with WW and 247 were immediately treated. The median follow-up duration was 75 months (range: 7–169). The estimated median time to treatment failure (TTF) in the treatment following WW cohort and immediate treatment cohort were 92 months (95 % CI, 60.1–NA) and 77 months (95 % CI, 65.1–107.6), respectively, which were not significantly different (P = 0.272) . In a multivariate analysis, clinical stage was identified as a predictive factor of TTF (HR 1.19, 95 % CI, 1.03–1.38, P < 0.05). Neither overall survival rate nor cumulative risk of transformation between the WW cohort and immediate treatment cohort was significant. The results of the present study suggested that the WW strategy is still an acceptable approach for selected FL patients in the rituximab era.