Differentiating Patients with Parkinson’s Disease from Normal Controls Using Gray Matter in the Cerebellum

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• 作者：Ling-Li Zeng ; Liang Xie ; Hui Shen ; Zhiguo Luo ; Peng Fang ; Yanan Hou…
• 关键词：Parkinson’s disease ; Magnetic resonance imaging ; Cerebellum ; Support vector machine
• 刊名：The Cerebellum
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：16
• 期：1
• 页码：151-157
• 全文大小：
• 刊物主题：Neurosciences; Neurology; Neurobiology;
• 出版者：Springer US
• ISSN：1473-4230
• 卷排序：16

文摘

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the world. Previous studies have focused on the basal ganglia and cerebral cortices. To date, the cerebellum has not been systematically investigated in patients with PD. In the current study, 45 probable PD patients and 40 age- and gender-matched healthy controls underwent structural magnetic resonance imaging, and we used support vector machines combining with voxel-based morphometry to explore the cerebellar structural changes in the probable PD patients relative to healthy controls. The results revealed that the gray matter alterations were primarily located within the cerebellar Crus I, implying a possible important role of this region in PD. Furthermore, the gray matter alterations in the cerebellum could differentiate the probable PD patients from healthy controls with accuracies of more than 95 % (p < 0.001, permutation test) via cross-validation, suggesting the potential of analyzing the cerebellum in the clinical diagnosis of PD.