Neutrophil-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma
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- 作者：Xing Li (1) (2)
Zhan-Hong Chen (1) (2)
Xiao-Kun Ma (1) (2)
Jie Chen (1) (2)
Dong-Hao Wu (1) (2)
Qu Lin (1) (2)
Min Dong (1) (2)
Li Wei (1) (2)
Tian-Tian Wang (1) (2)
Dan-Yun Ruan (1) (2)
Ze-Xiao Lin (1) (2)
Yan-Fang Xing (2) (3)
Yun Deng (2) (4)
Xiang-Yuan Wu (1) (2)
Jin-Yun Wen (1) (2) - 关键词：Neutrophil ; lymphocyte ratio ; Hepatocellular carcinoma ; Prognosis ; Blood cell counts ; Score system
- 刊名：Tumor Biology
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：35
- 期：11
- 页码：11057-11063
- 全文大小：313 KB
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12. Xue TC, Zhang L, Xie XY, Ge NL, Li LX, Zhang BH, et al. Prognostic significance of the neutrophil-to-lymphocyte ratio in primary liver cancer: a meta-analysis. PLoS One. 2014;9:e96072. CrossRef
13. Nakayama Y, Gotohda N, Shibasaki H, Nomura S, Kinoshita T, Hayashi R: Usefulness of the neutrophil/lymphocyte ratio measured preoperatively as a predictor of peritoneal metastasis in patients with advanced gastric cancer. Surg Today 2014. doi:10.1007/s00595-014-0917-1
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15. Fu SJ, Shen SL, Li SQ, Hua YP, Hu WJ, Liang LJ, et al. Prognostic value of preoperative peripheral neutrophil-to-lymphocyte ratio in patients wit - 作者单位：Xing Li (1) (2)
Zhan-Hong Chen (1) (2)
Xiao-Kun Ma (1) (2)
Jie Chen (1) (2)
Dong-Hao Wu (1) (2)
Qu Lin (1) (2)
Min Dong (1) (2)
Li Wei (1) (2)
Tian-Tian Wang (1) (2)
Dan-Yun Ruan (1) (2)
Ze-Xiao Lin (1) (2)
Yan-Fang Xing (2) (3)
Yun Deng (2) (4)
Xiang-Yuan Wu (1) (2)
Jin-Yun Wen (1) (2)
1. Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People’s Republic of China
2. Department of Medical Oncology, Shenzhen People’s Hospital, 1017 Dongmenbei Road, Shenzhen, 518020, People’s Republic of China
3. Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, 63 Duobao Road, Guangzhou, 510150, People’s Republic of China
4. Department of Radiation Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, 52 Meihua Dong Road, Zhuhai, People’s Republic of China - ISSN：1423-0380
文摘
Few studies investigated the prognosis of patients with advanced hepatocellular carcinoma (aHCC). This study was aimed to determine the prognostic value of differential blood cell counts including blood white cells, neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR), and platelet in patients with aHCC. A total of 205 ethnic Chinese aHCC patients receiving non-systematic sorafenib were analyzed retrospectively. The prognostic value of differential blood cell counts and NLR for overall survival (OS) was determined by integration into Cancer of the Liver Italian Program (CLIP) score system using backward elimination model of multivariate Cox regression. As a result, NLR was confirmed to be an independent predictor for OS (p--.001) with the rest parameters presented negative results. Then, aHCC patients were dichotomized into two groups according to NLR values ?.43 or >2.43. Patients with low NLR presented lower CLIP score and higher 6-month survival rate (56.1 vs 25.9?%) compared with patients with high NLR level. Besides, low NLR level was associated with favorable prognostic factors such as lower α-fetoprotein, alkaline phosphatase, and total bilirubin, as well as decreased incidence of ascites, portal vein thrombosis, and metastasis. Besides, low NLR level was associated less white cells and neutrophil granulocytes, as well as more lymphocyte. In summary, the present study firstly indentified NLR as an independent prognostic factor in aHCC patients receiving no systematic sorafenib.