Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets
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- 作者：Huan-sheng Yang ; Fei Wu ; Li-na Long ; Tie-jun Li…
- 关键词：Key wordsYeast products ; Weaned piglet ; Intestinal morphology ; Barrier function ; Antioxidant system
- 刊名：Journal of Zhejiang University SCIENCE B
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：17
- 期：10
- 页码：752-762
- 全文大小：592 KB
- 刊物主题：Biomedicine general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1862-1783
- 卷排序：17
文摘
The goal of this study was to evaluate the effects of a mixture of yeast culture, cell wall hydrolysates, and yeast extracts (collectively “yeast products,” YP) on the performance, intestinal physiology, and health of weaned piglets. A total of 90 piglets weaned at 21 d of age were blocked by body weight, sex, and litter and randomly assigned to one of three treatments for a 14-d feeding experiment, including (1) a basal diet (control), (2) 1.2 g/kg of YP, and (3) 20 mg/kg of colistin sulfate (CSE). No statistically significant differences were observed in average daily feed intake, average daily weight gain, or gain-to-feed ratio among CSE, YP, and control piglets. Increased prevalence of diarrhea was observed among piglets fed the YP diet, whereas diarrhea was less prevalent among those fed CSE. Duodenal and jejunal villus height and duodenal crypt depth were greater in the control group than they were in the YP or CSE groups. Intraepithelial lymphocytes (IEL) in the duodenal and jejunal villi were enhanced by YP, whereas IEL in the ileal villi were reduced in weaned piglets fed YP. Secretion of jejunal and ileal interleukin-10 (IL-10) was higher and intestinal and serum antioxidant indexes were affected by YP and CSE. In YP- and CSE-supplemented animals, serum D-lactate concentration and diamine oxidase (DAO) activity were both increased, and intestinal mRNA expressions of occludin and ZO-1 were reduced as compared to the control animals. In conclusion, YP supplementation in the diets of weaned piglets appears to increase the incidence of diarrhea and has adverse effects on intestinal morphology and barrier function.