Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population

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• 作者：GuoXiang Wang ; Hui Zhang ; FeiFang He and XiangMing Fang
• 关键词：Cytochrome P450 2D6 ; Allele frequency ; Tramadol ; Postoperative pain ; Chinese population
• 刊名：European Journal of Clinical Pharmacology
• 出版年：2006
• 出版时间：November, 2006
• 年：2006
• 卷：62
• 期：11
• 页码：927-931
• 全文大小：110 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1041

文摘

Objective The CYP2D6*10 allele is the most common allele with a frequency ranging from 51.3 to 70% and correlated with a significantly reduced metabolic activity in a Chinese population. The aim of the present study was to investigate whether the CYP2D6*10 allele has an impact on the postoperative analgesia effect of tramadol in Chinese patients recovering from major abdominal surgery.