Thoracic fat volume is independently associated with coronary vasomotion
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  • 作者:Vincent Dunet ; François Feihl ; Amin Dabiri…
  • 关键词:Thoracic fat ; Endothelial function ; Myocardial blood flow ; PET
  • 刊名:European Journal of Nuclear Medicine and Molecular Imaging
  • 出版年:2016
  • 出版时间:February 2016
  • 年:2016
  • 卷:43
  • 期:2
  • 页码:280-287
  • 全文大小:540 KB
  • 参考文献:1.Cheng VY, Dey D, Tamarappoo B, Nakazato R, Gransar H, Miranda-Peats R, et al. Pericardial fat burden on ECG-gated noncontrast CT in asymptomatic patients who subsequently experience adverse cardiovascular events. JACC Cardiovasc Imaging. 2010;3:352–60.PubMed PubMedCentral CrossRef
    2.Konishi M, Sugiyama S, Sugamura K, Nozaki T, Ohba K, Matsubara J, et al. Association of pericardial fat accumulation rather than abdominal obesity with coronary atherosclerotic plaque formation in patients with suspected coronary artery disease. Atherosclerosis. 2010;209:573–8.PubMed CrossRef
    3.Sade LE, Eroglu S, Bozbas H, Ozbicer S, Hayran M, Haberal A, et al. Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries. Atherosclerosis. 2009;204:580–5.PubMed CrossRef
    4.Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl UC, et al. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:781–6.PubMed CrossRef
    5.Kim TH, Yu SH, Choi SH, Yoon JW, Kang SM, Chun EJ, et al. Pericardial Fat amount is an independent risk factor of coronary artery stenosis assessed by multidetector-row computed tomography: the Korean atherosclerosis study 2. Obesity. 2010;19:1028–34.PubMed CrossRef
    6.Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, et al. Echocardiographic epicardial fat thickness and coronary artery disease. Circ J : Off J Jpn Circ Soc. 2007;71:536–9.CrossRef
    7.Bucci M, Joutsiniemi E, Saraste A, Kajander S, Ukkonen H, Saraste M, et al. Intrapericardial, but Not extrapericardial, fat is an independent predictor of impaired hyperemic coronary perfusion in coronary artery disease. Arterioscler Thromb Vasc Biol. 2011;31:211–8.PubMed CrossRef
    8.Aydin H, Toprak A, Deyneli O, Yazici D, Tarcin O, Sancak S, et al. Epicardial fat tissue thickness correlates with endothelial dysfunction and other cardiovascular risk factors in patients with metabolic syndrome. Metab Syndr Relat Disord. 2010;8:229–34.PubMed CrossRef
    9.Yoshinaga K, Manabe O, Katoh C, Chen L, Klein R, Naya M, et al. Quantitative analysis of coronary endothelial function with generator-produced (82)Rb PET: comparison with (15)O-labelled water PET. Eur J Nucl Med Mol Imaging. 2010;37:2233–41.PubMed CrossRef
    10.Lortie M, Beanlands RS, Yoshinaga K, Klein R, Dasilva JN, DeKemp RA. Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765–74.PubMed CrossRef
    11.Senthamizhchelvan S, Bravo PE, Esaias C, Lodge MA, Merrill J, Hobbs RF, et al. Human biodistribution and radiation dosimetry of 82Rb. J Nucl Med. 2010;51:1592–9.PubMed PubMedCentral CrossRef
    12.Einstein AJ, Moser KW, Thompson RC, Cerqueira MD, Henzlova MJ. Radiation dose to patients from cardiac diagnostic imaging. Circulation. 2007;116:1290–305.PubMed CrossRef
    13.Park MJ, Jung JI, Oh YS, Youn HJ. Assessment of epicardial fat volume with threshold-based 3-dimensional segmentation in CT: comparison with the 2-dimensional short axis-based method. Korean Circ J. 2010;40:328–33.PubMed PubMedCentral CrossRef
    14.Dormann CF, Elith J, Bacher S, Buchmann C, Carl G, Carre G, et al. Collinearity: a review of methods to deal with it and a simulation study evaluating their performance. Ecography. 2013;36:027–46.CrossRef
    15.Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation. 2008;117:605–13.PubMed CrossRef
    16.Fain JN. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm. 2006;74:443–77.PubMed CrossRef
    17.Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Mol Med. 2008;14:741–51.PubMed PubMedCentral CrossRef
    18.Cleland SJ, Sattar N, Petrie JR, Forouhi NG, Elliott HL, Connell JM. Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease. Clin Sci (Lond). 2000;98:531–5.CrossRef
    19.Devaraj S, Valleggi S, Siegel D, Jialal I. Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome. Curr Atheroscler Rep. 2010;12:110–8.PubMed PubMedCentral CrossRef
    20.Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Pfisterer M, et al. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. Arterioscler Thromb Vasc Biol. 2003;23:495–501.PubMed CrossRef
    21.Campisi R, Czernin J, Schoder H, Sayre JW, Schelbert HR. L-Arginine normalizes coronary vasomotion in long-term smokers. Circulation. 1999;99:491–7.PubMed CrossRef
    22.Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet. 1991;338:1546–50.PubMed CrossRef
    23.Morita K, Tsukamoto T, Naya M, Noriyasu K, Inubushi M, Shiga T, et al. Smoking cessation normalizes coronary endothelial vasomotor response assessed with 15O-water and PET in healthy young smokers. J Nucl Med. 2006;47:1914–20.PubMed
    24.Schindler TH, Campisi R, Dorsey D, Prior JO, Olschewski M, Sayre J, et al. Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors. Eur Heart J. 2009;30:978–86.PubMed PubMedCentral CrossRef
    25.Schindler TH, Facta AD, Prior JO, Cadenas J, Hsueh WA, Quinones MJ, et al. Improvement in coronary vascular dysfunction produced with euglycaemic control in patients with type 2 diabetes. Heart. 2007;93:345–9.PubMed PubMedCentral CrossRef
    26.Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. 2003;46:459–69.PubMed
    27.Prior JO, Quinones MJ, Hernandez-Pampaloni M, Facta AD, Schindler TH, Sayre JW, et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111:2291–8.PubMed CrossRef
    28.Payne GA, Borbouse L, Kumar S, Neeb Z, Alloosh M, Sturek M, et al. Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-{beta} pathway. Arterioscler Thromb Vasc Biol. 2010;30:1711–7.PubMed PubMedCentral CrossRef
    29.Barandier C, Montani JP, Yang Z. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity. Am J Physiol Heart Circ Physiol. 2005;289:H1807–13.PubMed CrossRef
    30.Saam T, Rominger A, Wolpers S, Nikolaou K, Rist C, Greif M, et al. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: a PET/CT study. Eur J Nucl Med Mol Imaging. 2010;37:1203–12.PubMed CrossRef
  • 作者单位:Vincent Dunet (1)
    François Feihl (2)
    Amin Dabiri (2)
    Gilles Allenbach (1)
    Bernard Waeber (2)
    Raphaël Heinzer (3)
    John O. Prior (1)

    1. Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland
    2. Department of Clinical Physiopathology, Lausanne University Hospital, Lausanne, Switzerland
    3. Center for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland
  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Nuclear Medicine
    Imaging and Radiology
    Orthopedics
    Cardiology
    Oncology
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1619-7089
文摘
Purpose Thoracic fat has been associated with an increased risk of coronary artery disease (CAD). As endothelium-dependent vasoreactivity is a surrogate of cardiovascular events and is impaired early in atherosclerosis, we aimed at assessing the possible relationship between thoracic fat volume (TFV) and endothelium-dependent coronary vasomotion.

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