Blocking Ihh signaling pathway inhibits the proliferation and promotes the apoptosis of PSCs
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  • 作者:Kai Xu (1)
    Fengjing Guo (1)
    Shuwei Zhang (1)
    Cheng Liu (1)
    Feixiong Wang (1)
    Zhiguo Zhou (1)
    Anmin Chen (1)
  • 关键词:precartilaginous stem cells ; proliferation ; apoptosis ; Indian hedgehog signaling pathway
  • 刊名:Journal of Huazhong University of Science and Technology [Medical Sciences]
  • 出版年:2009
  • 出版时间:February 2009
  • 年:2009
  • 卷:29
  • 期:1
  • 页码:39-44
  • 全文大小:953KB
  • 参考文献:1. Robinson D, Hasharoni A, Cohen N, / et al. Fibroblast growth factor receptor-3 as a marker for precartilaginous stem cells. Clin Orthop Relat Res, 1999,(367 Suppl):S163–S175
    2. Guo FJ, Chen AM, Huang SL. Immunological separation and immortalization induction of rat precartilaginous stem cells. Chin J Exp Surg (Chinese), 2007,24(2):226-28
    3. Ingham PW, Mc Mahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev, 2001,15(23):3059-087 CrossRef
    4. Chung U, Schipani E, Mc Mahon AP, / et al. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest, 2001,107(3):295-04 CrossRef
    5. Thayer SP, Magliano MP, Heiser PW, / et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003,425(6960):851-56 CrossRef
    6. Taipale J, Chen JK, Cooper MK, / et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature, 2000,406(6799):1005-009 CrossRef
    7. Chen JK, Taipale J, Cooper MK, / et al. Inhibition of hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev, 2002,16(21):2743-748 CrossRef
    8. Denef N, Neubuser D, Perez L, / et al. Hedgehog induces opposite changes in turnover and subcellular localization of patched and Smoothened. Cell, 2000,102:521-31 CrossRef
    9. Taipale J, Cooper MK, Maiti T, / et al. Patched acts catalytically to suppress the activity of Smoothened. Nature, 2002,418: 892-97 CrossRef
    10. Incardona JP, Gaffield W, Kapur RP, / et al. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development, 1998,125:3553-562
    11. Berman DM, Karhadkar SS, Maitra A, / et al. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003,425:846-51 CrossRef
    12. Karp SJ, Schipani E, St-Jacques B, / et al. Indian hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways. Development, 2000,127(3):543-48
    13. Ohta M, Tateishi K, Kanai F, / et al. p53-Independent negative regulation of p21/cyclin-dependent kinaseinteracting protein by the sonic hedgehog gliomaassociated oncogene pathway in gastric carcinoma cells. Cancer Res, 2005,65(23):10 822-0 829 CrossRef
    14. Massague J. G1 cell-cycle control and cancer. Nature, 2004,432:298-06 CrossRef
    15. van de Wetering M, Sancho E, Verweij C, / et al. The h-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell, 2002,111:241-50 CrossRef
    16. Seoane J, Le HV, Shen L, / et al. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell, 2004,117:211-23 CrossRef
    17. Regl G, Kasper M, Schnidar H, / et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res, 2004, 64(21):7724-731 CrossRef
  • 作者单位:Kai Xu (1)
    Fengjing Guo (1)
    Shuwei Zhang (1)
    Cheng Liu (1)
    Feixiong Wang (1)
    Zhiguo Zhou (1)
    Anmin Chen (1)

    1. Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
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