Adipose tissue macrophages in non-rodent mammals: a comparative study

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• 作者：Grace Ampem ; Hind Azegrouz ; Árpád Bacsadi ; Lajos Balogh…
• 关键词：Macrophages ; Adipose tissue ; Inflammation ; Alternative activation ; Metabolism ; Mammals
• 刊名：Cell and Tissue Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：363
• 期：2
• 页码：461-478
• 全文大小：6,387 KB
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• 作者单位：Grace Ampem (1)
  Hind Azegrouz (2)
  Árpád Bacsadi (3)
  Lajos Balogh (4)
  Susanne Schmidt (1)
  Julianna Thuróczy (5)
  Tamás Röszer (1)
  
  1. Institute for Comparative Molecular Endocrinology, University of Ulm, Ulm, Germany
  2. Massachusetts Institute of Technology, Cambridge, USA
  3. Laboratory of Pathology and Bacteriology, Veterinary Diagnostic Directorate, Debrecen, Hungary
  4. Frédéric Joliot-Curie National Institute of Radiobiology and Radiohygiene, Budapest, Hungary
  5. Department of Obstetrics and Reproduction, Faculty of Veterinary Science, Szent István University, Budapest, Hungary
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

The stromal vascular fraction (SVF) of adipose tissue in rodents and primates contains mesenchymal stem cells and immune cells. SVF cells have complex metabolic, immune and endocrine functions with biomedical impact. However, in other mammals, the amount of data on SVF stem cells is negligible and whether the SVF hosts immune cells is unknown. In this study, we show that the SVF is rich in immune cells, with a dominance of adipose tissue macrophages (ATMs) in cattle (Bos primigenius taurus), domestic goat (Capra aegagrus hircus), domestic sheep (Ovis aries), domestic cat (Felis catus) and domestic dog (Canis familiaris). ATMs of these species are granulated lysosome-rich cells with lamellipodial protrusions and express the lysosome markers acid phosphatase 5 (ACP-5) and Mac-3/Lamp-2. Using ACP-5 and Mac-3/Lamp-2 as markers, we additionally detected ATMs in other species, such as the domestic horse (Equus ferus caballus), wild boar (Sus scrofa) and red fox (Vulpes vulpes). Feline and canine ATMs also express the murine macrophage marker F4/80 antigen. In the lean condition, the alternative macrophage activation marker CD206 is expressed by feline and canine ATMs and arginase-1 by feline ATMs. Obesity is associated with interleukin-6 and interferon gamma expression and with overt tyrosine nitration in both feline and canine ATMs. This resembles the obesity-induced phenotype switch of murine and human ATMs. Thus, we show, for the first time, that the presence of ATMs is a general trait of mammals. The interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals. Keywords Macrophages Adipose tissue Inflammation Alternative activation Metabolism Mammals