Fate and removal of various antibiotic resistance genes in typical pharmaceutical wastewater treatment systems

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• 作者：Wenchao Zhai ; Fengxia Yang ; Daqing Mao…
• 刊名：Environmental Science and Pollution Research
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：23
• 期：12
• 页码：12030-12038
• 全文大小：1,012 KB
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment
  Environment
  Atmospheric Protection, Air Quality Control and Air Pollution
  Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
  Industrial Pollution Prevention
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1614-7499
• 卷排序：23

文摘

The high levels of antibiotic residues in pharmaceutical wastewater treatment plants (PWWTPs) make these plants the hotspots for the proliferation of antibiotic resistance genes (ARGs). This study investigated the fate and removal of 11 ARG subtypes for sulfonamide, tetracycline, β-lactam, and macrolide resistance in each processing stage of two full-scale PWWTPs in northern China. The levels of typical ARG subtypes in the final effluents ranged from (2.56 ± 0.13) × 101 to (2.36 ± 0.11) × 107 copies/ml. The absolute abundance of ARGs in effluents accounted for only 0.03–78.1 % of influents of the two PWWTPs, while the majority of the ARGs were transported to the dewatered sludge with concentrations from (2.65 ± 0.43) × 105 to (4.27 ± 0.03) × 1010 copies/g dry weight (dw). The total loads of ARGs discharged through dewatered sludge plus effluent was 1.01–14.09-fold higher than that in the raw influents, suggesting the proliferation of ARGs occurred in the wastewater treatment. The proliferation of ARGs mainly occurs in biological treatment process, such as aeration tank, anoxic tank, sequencing batch reactor (SBR), and bio-contact oxidation, facilitates the proliferation of various ARGs, implying significant replication of certain ARG subtypes may be attributable to microbial growth. Chemical oxidation seems promising to remove ARGs, with removal efficiency ranged from 29.3 to 85.7 %, while the partial correlation analysis showed significant correlations between antibiotic concentration and ARG removal. Thus, the high antibiotic residues within the PWWTPs may have an influence on the proliferation, fate, and removal of the associated ARG subtypes.KeywordsAntibiotic resistance genesPharmaceutical wastewater treatment plantAntibioticsActivated sludgeSequencing batch reactorBio-contact oxidation