A critical overview of long non-coding RNA in glioma etiology 2016: an update
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- 作者：Yuan-Feng Gao ; Zhi-Bin Wang ; Tao Zhu ; Chen-Xue Mao ; Xiao-Yuan Mao ; Ling Li…
- 关键词：Glioma ; lncRNAs ; Functional roles ; Potential biomarkers and therapeutic targets
- 刊名：Tumor Biology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：37
- 期：11
- 页码：14403-14413
- 全文大小：
- 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
- 卷排序：37
文摘
With the development of whole genome and transcriptome sequencing technologies, a growing body of long non-coding RNAs (lncRNAs) has been identified and is receiving increasing attention. LncRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases, specifically glioma. It has been established that lncRNAs are differently expressed in the central nervous system and may play a vital role in glioma. As of June 2016, 20 lncRNAs have been identified that may play a role in glioma pathogenesis. Investigation into the role of lncRNAs in glioma may help to identify potential biomarkers which can improve the diagnosis and treatment of glioma. In this paper, we review current understanding of the function of lncRNAs in glioma initiation and progression.