A Registration Approach to Endoscopic Laser Speckle Contrast Imaging for Intrauterine Visualisation of Placental Vessels

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• 刊名：Lecture Notes in Computer Science
• 出版年：2015
• 出版时间：2015
• 年：2015
• 卷：9349
• 期：1
• 页码：455-462
• 全文大小：1,199 KB
• 参考文献：1.Hecht, N., Woitzik, J., König, S., Horn, P., Vajkoczy, P.: Laser speckle imaging allows real-time intraoperative blood flow assessment during neurosurgical procedures. Journal of Cerebral Blood Flow and Metabolism 33, 1000–1007 (2013)CrossRef
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• 作者单位：Gustavo Sato dos Santos (17) (18)
  Efthymios Maneas (17) (18)
  Daniil Nikitichev (18)
  Anamaria Barburas (18)
  Anna L. David (19)
  Jan Deprest (20)
  Adrien Desjardins (18)
  Tom Vercauteren (17) (18)
  Sebastien Ourselin (17) (18)
  
  17. Translational Imaging Group, CMIC, University College London, London, NW1 2HE, UK
  18. Dept. Med. Phys. and Biomed. Eng., University College London, London, WC1E 6BT, UK
  19. Institute for Women’s Health, University College London, London, WC1E 6HX, UK
  20. Dept. of Obstetrics, University Hospitals KU Leuven, Leuven, Belgium
  
• 丛书名：Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015
• ISBN：978-3-319-24553-9
• 刊物类别：Computer Science
• 刊物主题：Artificial Intelligence and Robotics
  Computer Communication Networks
  Software Engineering
  Data Encryption
  Database Management
  Computation by Abstract Devices
  Algorithm Analysis and Problem Complexity
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1611-3349

文摘

Intrauterine interventions such as twin-to-twin transfusion syndrome procedure require accurate mapping of the fetal placental vasculature to ensure complete photocoagulation of vascular anastomoses. However, surgeons are currently limited to fetoscopy and external ultrasound imaging, which are unable to accurately identify all vessels especially those that are narrow and at the periphery. Laser speckle contrast imaging (LSCI) is an optical method for imaging blood flow that is emerging as an intraoperative tool for neurosurgery. Here we explore the application of LSCI to minimally invasive fetal surgery, with an endoscopic LSCI system based on a 2.7-mm-diameter fetoscope. We establish using an optical phantom that it can image flow in 1-mm-diameter vessels as far as 4 mm below the surface. We demonstrate that a spatiotemporal algorithm produces the clearest images of vessels within 200 ms, and that speckle contrast images can be accurately registered using groupwise registration to correct for significant motion of target or probe. When tested on a perfused term ex vivo human placenta, our endoscopic LSCI system revealed small capillaries not evident in the fetoscopic images.