Native flexibility of structurally homologous proteins: insights from anisotropic network model

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• 作者：Ranja Sarkar
• 关键词：Anisotropic network model ; Fibronectin ; Flexibility ; Spring constant
• 刊名：BMC Biophysics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：765KB
• 刊物主题：Biological and Medical Physics, Biophysics; Life Sciences, general; Biological Techniques;
• 出版者：BioMed Central
• ISSN：2046-1682
• 卷排序：10

文摘

BackgroundSingle-molecule microscopic experiments can measure the mechanical response of proteins to pulling forces applied externally along different directions (inducing different residue pairs in the proteins by uniaxial tension). This response to external forces away from equilibrium should in principle, correlate with the flexibility or stiffness of proteins in their folded states. Here, a simple topology-based atomistic anisotropic network model (ANM) is shown which captures the protein flexibility as a fundamental property that determines the collective dynamics and hence, the protein conformations in native state.