Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice
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- 作者：Rinku Dutta ; Virender Kumar ; Yang Peng ; Ruby E. Evande…
- 关键词：KEY WORDSbiodistribution ; GDC ; 0449 ; liver fibrosis ; micelles
- 刊名：Pharmaceutical Research
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：34
- 期：3
- 页码：564-578
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
- 出版者：Springer US
- ISSN：1573-904X
- 卷排序：34
文摘
PurposesTo determine the pharmacokinetic parameters and biodistribution of GDC-0449 loaded polymeric micelles after systemic administration into common bile duct ligation (CBDL) induced liver fibrotic mice.