Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
详细信息 查看全文
- 作者：Ricarda Cortés-Vieyra (1)
Alejandro Bravo-Pati?o (1)
Juan J Valdez-Alarcón (1)
Marcos Cajero Juárez (1)
B Brett Finlay (2)
Víctor M Baizabal-Aguirre (1) (3) - 关键词：GSK3β ; NF ; κB ; Inflammation ; Virulence factors ; Bacterial infection
- 刊名：Journal of Inflammation
- 出版年：2012
- 出版时间：December 2012
- 年：2012
- 卷：9
- 期：1
- 全文大小：340KB
- 参考文献：1. Doble BW, Woodgett JR: GSK-3, tricks of the trade for a multi-tasking kinase. / J Cell Sci 2003, 116:1175-186. CrossRef
2. Jope RS, Johnson GV: The glamour and gloom of glycogen synthase kinase-3. / Trends Biochem Sci 2004, 29:95-02. CrossRef
3. Wang H, Brown J, Martin M: Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. / Cytokine 2011, 53:130-40. CrossRef
4. Beurel E, Michalek SM, Jope RS: Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). / Trends Immunol 2010, 31:24-1. CrossRef
5. Woodgett JR: Molecular cloning and expression of glycogen synthase kinase-3/factor A. / EMBO J 1990, 9:2431-438.
6. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR: Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. / Nature 2000, 406:86-0. CrossRef
7. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC: Beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. / Cancer Cell 2002, 2:323-34. CrossRef
8. MacAulay K, Doble BW, Patel S, Hansoita T, Sinclair EM, Drucker DJ, Nagy A, Woodgett JR: Glycogen synthase kinase 3α-specific regulation of murine hepatic glycogen metabolism. / Cell Metab 2007, 6:329-37. CrossRef
9. Bijur GN, Jope RS: Glycogen synthase kinase-3β is highly activated in nuclei and mitochondria. / Neuroreport 2003, 14:2415-419. CrossRef
10. Wang H, Brown J, Gu Z, García CA, Liang R, Alard P, Beurel E, Jope RS, Greenway T, Martin M: Convergence of the mammalian target of rapamycin complex1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory responses. / J Immunol 2011, 186:5217-226. CrossRef
11. Liu P, Cheng H, Roberts TM, Zhao JJ: Targeting the phosphoinositide 3-kinase pathway in cancer. / Nat Rev Drug Disc 2009, 8:627-44. CrossRef
12. Viatour P, Merville MP, Bours V, Chariot A: Phosphorylation of NF-kappaB and IkappaB proteins. Implications in cancer and inflammation. / Trends Biochem Sci 2005, 30:43-2. CrossRef
13. Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeada K, Akira S: Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. / Nature 2002, 420:324-29. CrossRef
14. Ghosh S, Hayden MS: New regulators of NF-kappaB in inflammation. / Nat Rev Immunol 2008, 8:837-48. CrossRef
15. Demarchi F, Bertoli C, Sandy P, Schneider C: Glycogen synthase kinase-3β regulates NF-κB1/p105 stability. / J Biol Chem 2003, 278:39583-9590. CrossRef
16. Graham JR, Tullai JW, Cooper GM: GSK-3 represses growth factor-inducible genes by inhibiting NF-kappaB in quiescent cells. / J Biol Chem 2010, 285:4472-480. CrossRef
17. Lawrence T, Fong C: The resolution of inflammation: anti-inflammatory roles for NF-kappaB. / Int J Biochem Cell Biol 2010, 42:519-23. CrossRef
18. Kumar H, Kawai T, Akira S: Pathogen recognition in the innate immune response. / Biochem J 2009, 420:1-6. CrossRef
19. Steinke JW, Borish L: Cytokines and chemokines. / J Allergy Clin Immunol 2006, 117:S441-S445. CrossRef
20. Lawrence T, Gilroy DW: Chronic inflammation: a failure of resolution? / Int J Exp Pathol 2007, 88:85-4. CrossRef
21. Commins SP, Borish L, Steinke JW: Immunologic messenger molecules: cytokines, interferons, and chemokines. / J Allergy Clin Immunol 2010, 125:S53-S72. CrossRef
22. Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG: Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. / Nat Immunol 2000, 1:533-40. CrossRef
23. Guha M, Mackman N: The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. / J Biol Chem 2002, 277:32124-2132. CrossRef
24. Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, Kadowaki T, Takeuchi T, Koyasu S: PI3K-mediated negative feedback regulation of IL-12 production in DCs. / Nat Immunol 2002, 3:875-81. CrossRef
25. Fukao T, Yamada T, Tanabe M, Terauchi Y, Ota T, Takayama T, Asano T, Takeuchi T, Kadowaki T, Hata Ji J, Koyasu S: Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. / Nat Immunol 2002, 3:295-04. CrossRef
26. Martin M, Schifferle RE, Cuesta N, Vogel SN, Katz J, Michalek SM: Role of the phosphatidylinositol 3 kinase–Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. / J Immunol 2003, 171:717-25.
27. Martin M, Rehani K, Jope RS, Michalek SM: Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. / Nat Immunol 2005, 6:777-84. CrossRef
28. Rehani K, Wang H, Garcia CA, Kinane DF, Martin M: Toll-like receptor mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. / J Immunol 2009, 182:547-53.
29. Molnarfi N, Gruaz L, Dayer JM, Burger D: Opposite regulation of IL-1β and secreted IL-1 receptor antagonist production by phosphatidylinositide 3-kinases in human monocytes activated by lipopolysaccharides or contact with T cells. / J Immunol 2007, 178:446-54.
30. Chan MM, Cheung BK, Li JC, Chan LL, Lau AS: A role for glycogen synthase kinase-3 in antagonizing mycobacterial immune evasion by negatively regulating IL-10 induction. / J Leukoc Biol 2009, 86:283-91. CrossRef
31. Zhao L, Lee JY, Hwang DH: The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway. / Biochem Pharmacol 2008, 75:1515-525. CrossRef
32. Gutiérrez-Venegas G, Cardoso-Jiménez P: Lipoteichoic acid promotes nuclear accumulation of β-catenin via AKT in human gingival fibroblasts. / Int Immunopharmacol 2011, 11:1278-284. CrossRef
33. Duan Y, Liao AP, Kuppireddi S, Ye Z, Ciancio MJ, Sun J: beta-catenin activity negatively regulates bacteria-induced inflammation. / Lab Invest 2007, 87:613-24. CrossRef
34. Anson M, Crain-Denoyelle AM, Baud V, Chereau F, Gougelet A, Terris B, Yamagoe S, Colnot S, Viguier M, Perret C, Couty JP: Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice. / J Clin Invest 2012, 122:586-99. CrossRef
35. Ha T, Hu Y, Liu L, Lu C, McMullen JR, Kelley J, Kao RL, Williams DL, Gao X, Li C: TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism. / Cardiovasc Res 2010, 87:694-03. CrossRef
36. Shen E, Fan J, Peng T: Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation. / J Cell Biochem 2008, 104:329-38. CrossRef
37. Wang H, Garcia CA, Rehani K, Cekic C, Alard P, Kinane DF, Mitchell T, Martin M: IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. / J Immunol 2008, 181:6797-802.
38. Cremer TJ, Shah P, Cormet-Boyaka E, Valvano MA, Butchar JP, Tridandapani S: Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism. / J Immunol 2011, 187:635-43. CrossRef
39. Hu X, Paik PK, Chen J, Yarilina A, Kockeritz L, Lu TT, Woodgett JR, Ivashkiv LB: IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. / Immunity 2006, 24:563-74. CrossRef
40. Cheng YL, Wang CY, Huang WC, Tsai CC, Chen CL, Shen CF, Chi CY, Lin CF: Staphylococcus aureus induces microglial inflammation via a glycogen synthase kinase 3{beta}-regulated pathway. / Infect Immun 2009, 77:4002-008. CrossRef
41. Wang MJ, Huang HY, Chen WF, Chang HF, Kuo JS: Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades. / J Neuroinflammation 2010, 7:99. CrossRef
42. Lin CF, Tsai CC, Huang WC, Wang CY, Tseng HC, Wang Y, Kai JI, Wang SW, Cheng YL: IFN-gamma synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10. / J Cell Biochem 2008, 105:746-55. CrossRef
43. Beurel E, Jope RS: Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. / J Neuroinflammation 2009, 6:9. CrossRef
44. Fujikawa A, Shirasaka D, Yamamoto S, Ota H, Yahiro K, Fukuda M, Shintani T, Wada A, Aoyama N, Hirayama T, Fukamachi H, Noda M: Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori . / Nat Genet 2003, 33:375-81. CrossRef
45. Voskas D, Ling LS, Woodgett JR: Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? / F1000 Biol Rep 2010, 2:82.
46. Nakayama M, Hisatsune J, Yamasaki E, Isomotor H, Kurazono H, Hatakeyama M, Azuma T, Yamaoka Y, Yahiro K, Moss J, Hirayama T: Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway. / J Biol Chem 2009, 284:1612-619. CrossRef
47. Ha SD, Ng D, Pelech SL, Kim SO: Critical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages. / J Biol Chem 2007, 282:36230-6239. CrossRef
48. Burnham CA, Shokoples SE, Tyrrell GJ: Invasion of HeLa cells by group B Streptococcus requires the phosphoinositide-3-kinase signaling pathway and modulates phosphorylation of host cell Akt and glycogen synthase kinase-3. / Microbiology 2007, 153:4240-252. CrossRef
49. Ly KT, Casanova JE: Mechanisms of Salmonella entry into host cells. / Cell Microbiol 2007, 9:2103-111. CrossRef
50. Molero C, Rodríguez-Escudero I, Alemán A, Rotger R, Molina M, Cid VJ: Addressing the effects of Salmonella internalization in host cell signaling on a reverse-phase protein array. / Proteomics 2009, 9:3652-665. CrossRef
51. Oviedo-Boyso J, Cortés-Vieyra R, Huante-Mendoza A, Yu HB, Valdez-Alarcón JJ, Bravo-Pati?o A, Cajero-Juárez M, Finlay BB, Baizabal-Aguirre VM: The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. / Infect Immun 2011, 79:4569-577. CrossRef
52. Cai X, Li M, Vrana J, Schaller MD: Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. / Mol Cell Biol 2006, 26:2857-868. CrossRef - 作者单位：Ricarda Cortés-Vieyra (1)
Alejandro Bravo-Pati?o (1)
Juan J Valdez-Alarcón (1)
Marcos Cajero Juárez (1)
B Brett Finlay (2)
Víctor M Baizabal-Aguirre (1) (3)
1. Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico
2. Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
3. Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Km. 9.5 s/n Carretera Morelia-Zinapécuaro, La Palma, Tarímbaro, C.P. 58893, Morelia, Michoacán, Mexico - ISSN：1476-9255
文摘
Glycogen synthase kinase 3β (GSK3β) plays a fundamental role during the inflammatory response induced by bacteria. Depending on the pathogen and its virulence factors, the type of cell and probably the context in which the interaction between host cells and bacteria takes place, GSK3β may promote or inhibit inflammation. The goal of this review is to discuss recent findings on the role of the inhibition or activation of GSK3β and its modulation of the inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level, mainly through the regulation of nuclear factor-kappaB (NF-κB) activity. Also included is a brief overview on the importance of GSK3 in non-inflammatory processes during bacterial infection.