Soft tissue sarcomas with non-EWS translocations: molecular genetic features and pathologic and clinical correlations

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• 作者：Cyril Fisher
• 关键词：Translocation ; Soft tissue sarcoma ; Molecular genetics
• 刊名：Virchows Archiv
• 出版年：2010
• 出版时间：February, 2010
• 年：2010
• 卷：456
• 期：2
• 页码：153-166
• 全文大小：1.1 MB

文摘

Many soft tissue sarcoma subtypes have consistent chromosomal translocations with novel fusion genes, which result in disordered cellular function. The microscopic appearances, immunophenotype and behaviour of such tumours relate to the genetic events to a variable extent. This paper reviews the molecular pathology and related morphological and clinical features of sarcomas with non-EWS translocations. These include synovial sarcoma, alveolar rhabdomyosarcoma, alveolar soft part sarcoma, dermatofibrosarcoma protuberans, low-grade fibromyxoid sarcoma, infantile fibrosarcoma and inflammatory myofibroblastic tumour.