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• 作者：A. G. A. W. Alakolanga ; N. Savitri Kumar…
• 关键词：Antioxidant ; Flacourtia inermis ; Malic acid ; α ; glucosidase inhibitor ; α ; amylase inhibitor ; Lipase inhibitor
• 刊名：Journal of Food Science and Technology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：52
• 期：12
• 页码：8383-8388
• 全文大小：341 KB
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• 作者单位：A. G. A. W. Alakolanga (1)
  N. Savitri Kumar (1)
  Lalith Jayasinghe (1)
  Yoshinori Fujimoto (2)
  
  1. Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka
  2. Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo, 152-8551, Japan
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  Chemistry
  
• 出版者：Springer India
• ISSN：0975-8402

文摘

Flacourtia inermis Roxb. (Flacourtiaceae), is a moderate sized tree cultivated in Sri Lanka for its fruits known as Lovi. The current study was undertaken to study the biological activity of extracts of the fruits in an attempt to increase the value of the under exploited fruit crops. Fruits of F. inermis were found to be rich in phenolics and anthocyanins. Polyphenol content of the fruits was determined to be 1.28 g gallic acid equivalents per 100 g of fresh fruit and anthocyanin content was estimated as 108 mg cyanidin-3-glucoside equivalents per 100 g of fresh fruits. The EtOAc extract showed moderate antioxidant activity in the DPPH radical scavenging assay with IC₅₀ value of 66.2 ppm. The EtOAc and MeOH extracts of the fruits also exhibited inhibitory activities toward α-glucosidase, α-amylase and lipase enzymes with IC₅₀values ranging from 549 to 710 ppm, 1021 to 1949 ppm and 1290 to 2096 ppm, respectively. The active principle for the enzyme inhibition was isolated through activity-guided fractionation and was characterized as (S)-malic acid. The results of this study indicate that F. inermis fruits have the potential to be used in health foods and in nutritional supplements. Keywords Antioxidant Flacourtia inermis Malic acid α-glucosidase inhibitor α-amylase inhibitor Lipase inhibitor