Invasive Pulmonary Aspergillosis in Patients with Chronic Obstructive Pulmonary Disease: An Emerging Fungal Disease

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• 作者：Florence Ader (1) (2) (3)
  
• 关键词：Invasive pulmonary aspergillosis ; Aspergillus ; Chronic obstructive pulmonary disease ; Corticosteroids
• 刊名：Current Infectious Disease Reports
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：12
• 期：6
• 页码：409-416
• 全文大小：161KB
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• 作者单位：Florence Ader (1) (2) (3)
  
  1. Department of Infectious Diseases, Croix-Rousse Hospital, Lyon, 69004, France
  2. Inserm U851 Finovi Centre d鈥橧nfectiologie Innate Immunity and Bacterial Pathogenesis, Claude Bernard Lyon 1 University, Lyon, 69007, France
  3. Inserm U851, Finovi Centre d鈥橧nfectiologie, B芒timent DomiLyon, 321 avenue Jean Jaur猫s, 69007, Lyon, France
  

文摘

Invasive pulmonary aspergillosis (IPA) is a necrotizing pneumonia caused by airborne opportunistic fungi of Aspergillus species. Patients with advanced-stage chronic obstructive pulmonary disease (COPD) have emerged to be at risk for IPA as a result of the overall improvement of long-term management of the disease. IPA is among the most severe infectious event that may occur during the course of COPD resulting from profound immune impairment and associated with poor outcome. Many aspects of the development of IPA in COPD patients differ from hematologic patients, explaining various patterns of IPA in an expanded population of immunocompromised patients. Therefore, it is legitimate to focus on the literature-based data available regarding the factors involved in the development of IPA in this setting as well as the use and interpretation of diagnosis criteria, and the treatment options.