Seizure outcomes in relation to the extent of resection of the perifocal fluorodeoxyglucose and flumazenil PET abnormalities in anteromedial temporal lobectomy

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• 作者：Milo Stani?i? ; Christopher Coello ; Jugoslav Ivanovi? ; Arild Egge…
• 关键词：Temporal lobe epilepsy ; 18F ; FDG ; PET ; 11C ; FMZ ; PET ; Post ; operative outcome
• 刊名：Acta Neurochirurgica
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：157
• 期：11
• 页码：1905-1916
• 全文大小：1,345 KB
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• 作者单位：Milo Stani?i? (1)
  Christopher Coello (2)
  Jugoslav Ivanovi? (1)
  Arild Egge (1)
  Torsten Danfors (3)
  John Hald (4)
  Einar Heminghyt (5)
  Marjan Makki Mikkelsen (6)
  B?rd Kronen Krossnes (7)
  Are Hugo Pripp (8)
  P?l Gunnar Larsson (9)
  
  1. Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway
  2. PET Core Facility/PET Centre, Oslo University Hospital, Oslo, Norway
  3. Section of Nuclear Medicine & PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
  4. Department of Radiology, Oslo University Hospital, Oslo, Norway
  5. Department of Clinical Psychology and Neuropsychology, National Center for Epilepsy, Oslo University Hospital, Oslo, Norway
  6. Department of Adult Epilepsy, National Center for Epilepsy, Oslo University Hospital, Oslo, Norway
  7. Department of Pathology, Oslo University Hospital, Oslo, Norway
  8. Oslo Center of Biostatistics and Epidemiology, Research Support Service, Oslo University Hospital, Oslo, Norway
  9. Clinical Neurophysiologic Laboratories, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway
  
• 刊物主题：Neurosurgery; Interventional Radiology; Neuroradiology; Neurology; Surgical Orthopedics; Minimally Invasive Surgery;
• 出版者：Springer Vienna
• ISSN：0942-0940

文摘

Background The area of predominant perifocal [18F]fluorodeoxyglucose (18F-FDG) hypometabolism and reduced [11C]flumazenil (11C-FMZ) -binding on PET scans is currently considered to contain the epileptogenic zone and corresponds anatomically to the area localizing epileptogenicity in patients with temporal lobe epilepsy (TLE). The question is whether the volume of the perifocal pre-operative PET abnormalities, the extent of their resection, and the volume of the non-resected abnormalities affects the post-operative seizure outcome.