OCT-Angiographie bei der exsudativen altersbedingten Makuladegeneration

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• 作者：PD Dr. A. Lommatzsch ; M.-L. Farecki ; B. Book ; B. Heimes…
• 关键词：Fluorescence angiography ; Retina ; Choroid ; Choroidal neovascularization ; Artefacts
• 刊名：Der Ophthalmologe
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：113
• 期：1
• 页码：23-29
• 全文大小：793 KB
• 参考文献：1.Bird AC, Marshall J (1986) Retinal pigment epithelial detachments in the elderly. Trans Ophthalmol Soc 105:674–682
  2.Chakravarthy U, Harding SP, Rogers CA et al (2013) Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial. Lancet 382:1258–1267CrossRef PubMed
  3.Clemens CR, Krohne TU, Charbel Issa P et al (2012) High-resolution optical coherence tomography of subpigment epithelial structures in patients with pigment epithelium detachment secondary to age-related macular degeneration. Br J Ophthalmol 96:1088–1091CrossRef PubMed
  4.Deutsche Ophthalmologische Gesellschaft, Retinologische Gesellschaft Berufsverbands der Augenärzte Deutschlands (2015) Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbandes der Augenärzte Deutschlands zu therapeutischen Strategien in der Anti-VEGF-Therapie bei der neovaskulären altersabhängigen Makuladegeneration. Ophthalmol 112:237–245CrossRef
  5.Gass JD (1984) Serous retinal pigment epithelial detachment with a notch. A sign of occult choroidal neovascularization. Retina 4:205–220CrossRef PubMed
  6.IVAN Study Investigators, Chakravarthy U, Harding SP et al (2012) Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Ophthalmology 119:1399–1411
  7.Kuehlewein L, Sadda SR, Sarraf D (2015) OCT angiography and sequential quantitative analysis of type 2 neovascularization after ranibizumab therapy. Eye 29:932–935CrossRef PubMed
  8.Lehmann B, Heimes B, Gutfleisch M et al (2015) Serous vascularized pigment epithelial detachment in exudative AMD. Morphological typing and risk of tears in the RPE. Ophthalmol 112:49–56CrossRef
  9.Moult E, Choi W, Waheed NK et al (2014) Ultrahigh-speed swept-source OCT angiography in exudative AMD. Ophthalmic Surg Lasers Imaging Retina 45:496–505PubMedCentral CrossRef PubMed
  10.Nagiel A, Sarraf D, Sadda SR et al (2015) Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography. Retina 35:638–647CrossRef PubMed
  11.Spaide RF (2015) Optical coherence tomography angiography signs of vascular abnormalization with antiangiogenic therapy for choroidal neovascularization. Am J Ophthalmol 160:6–16CrossRef PubMed
  12.Verteporfin Roundtable 2000 and 2001 Participants, Treatment of age-related macular degeneration with photodynamic therapy (TAP) study group principal investigators, Verteporfin in photodynamic therapy (VIP) study group principal investigators (2002) Guidelines for using verteporfin (visudyne) in photodynamic therapy to treat choroidal neovascularization due to age-related macular degeneration and other causes. Retina 22:6–18CrossRef
  13.Xu L, Mrejen S, Jung JJ et al (2015) Geographic atrophy in patients receiving anti-vascular endothelial growth factor for neovascular age-related macular degeneration. Retina 35:176–186CrossRef PubMed
  14.Yannuzzi LA, Negrão S, Iida T et al (2001) Retinal angiomatous proliferation in age-related macular degeneration. Retina 21:416–434CrossRef PubMed
  
• 作者单位：PD Dr. A. Lommatzsch (1)
  M.-L. Farecki (1)
  B. Book (1)
  B. Heimes (1)
  D. Pauleikhoff (1)
  
  1. Augenabteilung, St. Franziskus Hospital Münster, Hohenzollernring 74, 48145, Münster, Deutschland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-0423

文摘

The new technique of optical coherence tomography (OCT) angiography allows a non-invasive reconstruction of the three-dimensional structure of the total retinal and choroidal vascularization within seconds. There are still limitations caused by movement artefacts, superimposition of superficial retinal vessels at the retinal pigment epithelium (RPE) level and insufficient three-dimensional imaging modalities. Initial experiences with this new method and especially the correlation with the current standard diagnostic procedure of fluorescein angiography show that new information can be obtained regarding specific vascular and neovascular changes. For three-dimensional neovascular changes, such as those found in exudative age-related macular degeneration (AMD,) a more sophisticated diagnostic analysis strategy must be specifically developed. Initial experiences demonstrate that the differentiation into the various types of choroidal neovascularization (CNV) by fluorescein angiography, specifically for type 1 (occult) and type 2 (classical) can also be visualized by OCT angiography. Furthermore, the new technology provides additional information on the choroidal and outer retinal changes associated with this disease, which may result in a better understanding of the underlying pathology.