Symmetric Meso-Chloro-Substituted Pentamethine Cyanine Dyes Containing Benzothiazolyl/Benzoselenazolyl Chromophores Novel Synthetic Approach and Studies on Photophysical Properties upon Interaction with bio-Objects

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• 作者：Atanas Kurutos ; Olga Ryzhova ; Valeriya Trusova ; Galyna Gorbenko…
• 关键词：Pentamethine cyanine dyes ; 2 ; methylbenzothiazole ; 2 ; methylbenzoselenazole ; Fluorescent markers ; Liposomes ; DNA ; proteins ; H ; aggregates
• 刊名：Journal of Fluorescence
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：26
• 期：1
• 页码：177-187
• 全文大小：940 KB
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• 作者单位：Atanas Kurutos (1)
  Olga Ryzhova (2)
  Valeriya Trusova (2) (3)
  Galyna Gorbenko (2)
  Nikolay Gadjev (1)
  Todor Deligeorgiev (1)
  
  1. Sofia University “St. Kliment Ohridski”, Faculty of Chemistry and Pharmacy, 1, blv. J. Bourchier, 1164, Sofia, Bulgaria
  2. Department of Nuclear and Medical Physics, V.N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61077, Ukraine
  3. 19-32 Geroyev Truda, Kharkiv, 61044, Ukraine
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biophysics and Biomedical Physics
  Biotechnology
  Biochemistry
  Analytical Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4994

文摘

A series of symmetric pentamethine cyanine dyes derived from various N-substituted benzothiazolium/benzoselenazolium salts, and a conjugated bis-aniline derivative containing a chlorine atom at meso-position with respect to the polymethine chain, were synthesized using a novel improved synthetic approach under mild conditions at room temperature. The reaction procedure was held by grinding the starting compounds for relative short times. The novel method is reliable and highly reproducible. Some photophysical characteristics were recorded in various solvents, including absorption, and fluorescence quantum yields using Cy-5 as a reference. Additional studies on interactions with several bio-objects such as liposomes, DNA, and proteins have been investigated in the present work. Keywords Pentamethine cyanine dyes 2-methylbenzothiazole 2-methylbenzoselenazole Fluorescent markers Liposomes DNA, proteins H-aggregates