Phosphorus–nitrogen compounds
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- 作者：Hüseyin Akbaş ; Aytuğ Okumuş ; Ahmet Karadağ…
- 关键词：Phosphazene salts ; Thermal analysis ; Cytotoxic activity ; DNA binding ; Antimicrobial activity
- 刊名：Journal of Thermal Analysis and Calorimetry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：123
- 期：2
- 页码：1627-1641
- 全文大小：1,006 KB
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48.Green MR, Sambrook J. Molecular cloning. New York: Cold Spring Harbor Laboratory Press; 2012. - 作者单位：Hüseyin Akbaş (1)
Aytuğ Okumuş (2)
Ahmet Karadağ (1)
Zeynel Kılıç (2)
Tuncer Hökelek (3)
L. Yasemin Koç (4)
Leyla Açık (5)
Betül Aydın (5)
Mustafa Türk (6)
1. Department of Chemistry, Gaziosmanpaşa University, 60150, Taşlıçiftlik Kampüsü-Tokat, Turkey
2. Department of Chemistry, Ankara University, 06100, Tandoğan-Ankara, Turkey
3. Department of Physics, Hacettepe University, 06800, Beytepe-Ankara, Turkey
4. The Turkish Sugar Authority, 06510, Çankaya-Ankara, Turkey
5. Department of Biology, Gazi University, 06500, Teknikokullar-Ankara, Turkey
6. Department of Bioenginering, Kırıkkale University, Kırıkkale, Turkey - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Sciences
Polymer Sciences
Physical Chemistry
Inorganic Chemistry
Measurement Science and Instrumentation - 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
- ISSN：1572-8943
文摘
The salicylic acid salts of fully substituted mono(4-fluorobenzyl)spirocyclotriphosphazenes (10–15) were prepared. The structures of these phosphazenium salts (10a–15a) were determined by elemental analyses, FTIR and 1H, 13C{1H}, 31P{1H} NMR techniques. The crystal structure of 14a was verified by X-ray diffraction analysis. The thermal properties of the salts were investigated using TG/DTA and DSC instruments. The results obtained from DSC indicated that the melting temperatures and latent heats of the compounds were in the ranges of 107.76–143.04 °C and 41.64–69.73 J g−1, respectively. The thermal stabilities of the phosphazenium salts (10a–15a) are found to be different, but they have a similar decomposition mechanism. The compounds 14a and 15a exhibit noticeable cytotoxic activity against DLD-1 cancer cells, and they seem to be good candidates for being anticancer agents. All of the compounds have an antimicrobial effect on bacterial and yeast strains within the ranges of 312–625 µM (bacterial strains) and 19.5–312 µM (yeast strains). It is found that compounds 13a–15a were most effective against yeast strains. Moreover, interactions between the salts and pBR322 plasmid DNA show that 14a and 15a cleave the DNA and decrease the intensity of form I. BamHI and HindIII digestion results demonstrate that the compounds are not bound with G/G and A/A nucleotides, respectively. Keywords Phosphazene salts Thermal analysis Cytotoxic activity DNA binding Antimicrobial activity