IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals

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• 作者：Takehiro Kanda ; Makoto Ozawa ; Kyoko Tsukiyama-Kohara
• 关键词：FMDV ; IRES ; ITAF ; ITAF45 ; 4E ; BP1 ; PTB ; Translation
• 刊名：BMC Veterinary Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：1
• 全文大小：1,179 KB
• 刊物主题：Veterinary Medicine; Zoology; Transgenics;
• 出版者：BioMed Central
• ISSN：1746-6148

文摘

Background Foot-and-mouth disease virus (FMDV) possess a positive sense, single stranded RNA genome. Internal ribosomal entry site (IRES) element exists within its 5′ untranslated region (5′UTR) of the viral RNA. Translation of the viral RNA is initiated by internal entry of the 40S ribosome within the IRES element. This process is facilitated by cellular factors known as IRES trans-acting factors (ITAFs).