The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines

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• 作者：Toshirou Nishida ; Jean-Yves Blay ; Seiichi Hirota ; Yuko Kitagawa…
• 关键词：Gastrointestinal stromal tumor ; Guidelines ; Evidence ; based ; Consensus based
• 刊名：Gastric Cancer
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：19
• 期：1
• 页码：3-14
• 全文大小：523 KB
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• 作者单位：Toshirou Nishida (1)
  Jean-Yves Blay (2)
  Seiichi Hirota (3)
  Yuko Kitagawa (4)
  Yoon-Koo Kang (5)
  
  1. Department of Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan
  2. Department of Medical Oncology, Centre Leon-Bernard, University Claude Bernard Lyon I, Lyon, France
  3. Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
  4. Department of Surgery, Keio University School of Medicine, Tokyo, Japan
  5. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Gastroenterology
  Surgical Oncology
  Pathology
  Radiotherapy
  
• 出版者：Springer Japan
• ISSN：1436-3305

文摘

Although gastrointestinal stromal tumors (GISTs) are a rare type of cancer, they are the commonest sarcoma in the gastrointestinal tract. Molecularly targeted therapy, such as imatinib therapy, has revolutionized the treatment of advanced GIST and facilitates scientific research on GIST. Nevertheless, surgery remains a mainstay of treatment to obtain a permanent cure for GIST even in the era of targeted therapy. Many GIST guidelines have been published to guide the diagnosis and treatment of the disease. We review current versions of GIST guidelines published by the National Comprehensive Cancer Network, by the European Society for Medical Oncology, and in Japan. All clinical practice guidelines for GIST include recommendations based on evidence as well as on expert consensus. Most of the content is very similar, as represented by the following examples: GIST is a heterogeneous disease that may have mutations in KIT, PDGFRA, HRAS, NRAS, BRAF, NF1, or the succinate dehydrogenase complex, and these subsets of tumors have several distinctive features. Although there are some minor differences among the guidelines—for example, in the dose of imatinib recommended for exon 9-mutated GIST or the efficacy of antigen retrieval via immunohistochemistry—their common objectives regarding diagnosis and treatment are not only to improve the diagnosis of GIST and the prognosis of patients but also to control medical costs. This review describes the current standard diagnosis, treatment, and follow-up of GISTs based on the recommendations of several guidelines and expert consensus. Keywords Gastrointestinal stromal tumor Guidelines Evidence-based Consensus based