Six Degree-of-Freedom Measurements of Human Mild Traumatic Brain Injury
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- 作者：Fidel Hernandez ; Lyndia C. Wu ; Michael C. Yip…
- 关键词：Concussion ; Mild traumatic brain injury (mTBI) ; Instrumented mouthguard ; Six degree ; of ; freedom?(6DOF) kinematics ; Finite element model ; Brain strain
- 刊名：Annals of Biomedical Engineering
- 出版年：2015
- 出版时间：August 2015
- 年：2015
- 卷：43
- 期：8
- 页码：1918-1934
- 全文大小：1,870 KB
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Lyndia C. Wu (2)
Michael C. Yip (2)
Kaveh Laksari (2)
Andrew R. Hoffman (3)
Jaime R. Lopez (4)
Gerald A. Grant (5)
Svein Kleiven (6)
David B. Camarillo (1) (2)
1. Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
2. Department of Bioengineering, Stanford University, Stanford, CA, USA
3. Department of Medicine, Stanford University, Stanford, CA, USA
4. Department of Neurology, Stanford University, Stanford, CA, USA
5. Department of Neurosurgery, Stanford University, Stanford, CA, USA
6. Department of Neuronic Engineering, KTH Royal Institute of Technology, Stockholm, Sweden - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine
Biomedical Engineering
Biophysics and Biomedical Physics
Mechanics
Biochemistry - 出版者：Springer Netherlands
- ISSN：1573-9686
文摘
This preliminary study investigated whether direct measurement of head rotation improves prediction of mild traumatic brain injury (mTBI). Although many studies have implicated rotation as a primary cause of mTBI, regulatory safety standards use 3 degree-of-freedom (3DOF) translation-only kinematic criteria to predict injury. Direct 6DOF measurements of human head rotation (3DOF) and translation (3DOF) have not been previously available to examine whether additional DOFs improve injury prediction. We measured head impacts in American football, boxing, and mixed martial arts using 6DOF instrumented mouthguards, and predicted clinician-diagnosed injury using 12 existing kinematic criteria and 6 existing brain finite element (FE) criteria. Among 513 measured impacts were the first two 6DOF measurements of clinically diagnosed mTBI. For this dataset, 6DOF criteria were?the most predictive of injury, more than 3DOF translation-only and 3DOF rotation-only criteria. Peak principal strain in the corpus callosum, a 6DOF FE criteria, was the strongest predictor, followed by two criteria that included rotation measurements, peak rotational acceleration magnitude and Head Impact Power (HIP). These results suggest head rotation measurements may improve injury prediction. However, more 6DOF data is needed to confirm this evaluation of existing injury criteria, and to develop new criteria that considers directional sensitivity to injury.