Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless ‘Frank–Starling Gain-index
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- 作者：Christian Bollensdorff (1) (2) (4)
Oleg Lookin (3)
Peter Kohl (1) (2) - 关键词：Heart ; Stretch ; Positive inotropic response ; Cardiac mechanics ; Mechanosensitivity
- 刊名：Pfl眉gers Archiv - European Journal of Physiology
- 出版年：2011
- 出版时间：July 2011
- 年：2011
- 卷：462
- 期：1
- 页码：39-48
- 全文大小：364KB
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Oleg Lookin (3)
Peter Kohl (1) (2)
1. Cardiac Biophysics and Systems Biology, The National Heart and Lung Institute, Imperial College, London, UK
2. Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
4. Imperial College, National Heart and Lung Institute, Heart Science Centre, Hill End Road, Harefield, UB9 6JH, UK
3. Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, Russia - ISSN：1432-2013
文摘
This paper briefly recapitulates the Frank–Starling law of the heart, reviews approaches to establishing diastolic and systolic force–length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called ‘Frank–Starling Gain- calculated as the ratio of slopes of end-systolic and end-diastolic force–length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank–Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.