Overexpression of forkhead box protein M1 (FOXM1) plays a critical role in colorectal cancer

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• 作者：H. G. Zhang ; X. W. Xu ; X. P. Shi ; B. W. Han…
• 关键词：Colorectal cancer ; Forkhead box protein M1 ; Small interfering RNA ; Targeted therapy
• 刊名：Clinical and Translational Oncology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：18
• 期：5
• 页码：527-532
• 全文大小：940 KB
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• 作者单位：H. G. Zhang (1)
  X. W. Xu (2)
  X. P. Shi (1)
  B. W. Han (2)
  Z. H. Li (2)
  W. H. Ren (1)
  P. J. Chen (1)
  Y. F. Lou (1)
  B. Li (1)
  X. Y. Luo (1)
  
  1. Department of Oncology, The Affiliated Luoyang Central Hospital of Zhengzhou University, No. 288 Zhongzhou Road, Luoyang, 471000, China
  2. Department of Surgery, The Affiliated Luoyang Central Hospital of Zhengzhou University, Luoyang, 471000, China
  
• 刊物主题：Oncology;
• 出版者：Springer Milan
• ISSN：1699-3055

文摘

Background The forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. However, the clinical significance of FOXM1 signaling in human colorectal cancer (CRC) pathogenesis remains unknown. The aim of this study was to evaluate the role of FOXM1 in CRC tumorigenesis.