Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice

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• 作者：Woo-Young Jeon (1)
  In-Sik Shin (1) (2) (3)
  Hyeun-Kyoo Shin (1)
  Mee-Young Lee (1)
  
  1. Herbal Medicine Formulation Research Group ; Korea Institute of Oriental Medicine ; 483 Expo-ro ; Yusung-gu ; Daejeon ; 305-811 ; Republic of Korea
  2. Natural Medicine Research Center ; Korea Research Institute of Bioscience and Biotechnology ; 30 Yeongudanji-ro ; O-chang uep ; Cheongwon-gun ; Cheongju-si ; Chungbuk ; 363-883 ; Republic of Korea
  3. Pharmacology ; College of Veterinary Medicine ; Chonnam National University ; Gwangju ; 500-757 ; Republic of Korea
  
• 关键词：Samsoeum ; Asthma ; Inflammatory cells ; Th1/Th2 cytokines ; iNOS
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：1,891 KB
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• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882

文摘

Background Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. Methods Female BALB/c mice were sensitized by an intraperitoneal injection of OVA and subsequently challenged with nebulized OVA. We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells in lung tissue, the levels of immunoglobulin E (IgE) in BALF and plasma, and the expression of inducible nitric oxide synthase (iNOS) in lung tissue. Results Our findings indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW suppressed the level of IgE in BALF and plasma, and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells, and the expression of iNOS in lung tissue. Conclusions Collectively, these results suggest that, because of its anti-inflammatory and antiasthma properties, SSEW may be useful in reducing airway inflammation in the treatment of allergic asthma.