Ethnopharmacological and phytomedical knowledge of Coleus forskohlii: An approach towards its safety and therapeutic value
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- 作者：H. N. Shivaprasad (1)
Subrata Pandit (1)
M. Bhanumathy (1)
D. Manohar (1)
Vishal Jain (1)
Shariq Afsar Thandu (1)
Xiao Su (2) - 关键词：Coleus forskohlii ; Ayurveda ; Phytoconstituents ; Forskolin ; Ethnopharmacology ; Safety
- 刊名：Oriental Pharmacy and Experimental Medicine
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：14
- 期：4
- 页码：301-312
- 全文大小：638 KB
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20. de Almeida FM, de Britto e Alves MTSS, do Amaral FMM (2012) Use of plants with medicinal purposes by people living with HIV/ AIDS on antiretroviral therapy. Saude Soc 21:424-34 CrossRe - 作者单位：H. N. Shivaprasad (1)
Subrata Pandit (1)
M. Bhanumathy (1)
D. Manohar (1)
Vishal Jain (1)
Shariq Afsar Thandu (1)
Xiao Su (2)
1. Research and Development Centre, Olive Lifesciences Pvt. Ltd., No. 87, 1st Main, KIADB Industrial Area, Anthrasanahalli, Tumkur, 572106, Karnataka, India
2. College of Health and Biomedicine, Victoria University, St Albans Campus, PO Box 14428, Melbourne, VIC, 8001, Australia - ISSN：2211-1069
文摘
Coleus forskohlii Briq. (Family: Lamiaceae) is a fleshy perennial aromatic herb with fibrous roots that grows under tropical to temperate areas in India, Burma, Thailand, Nepal, Pakistan, Sri Lanka, East Africa and Brazil. The rootstock of the plant is used in Ayurveda and other systems of medicine for several ailments such as heart and lung conditions, asthma, digestive disorder, insomnia, muscle spasm, convulsion and skin diseases. Extensive literature survey was performed based on distribution, morphology, phytochemistry and pharmacological aspects of C. forskohlii through pubmed, scopus, SciFinder, google scholar, sciencedirect and ethnobotanical books. Phytopharmacological knowledge and cosmeceutical use of C. forskohlii and its bioactive constituents have been documented. Coleus roots are exclusive source of forskolin, commonly known as fat burning molecule. It’s unique property is activating of almost all hormone sensitive adenylate cyclase enzymes by cyclic 3-5-adenosine monophosphate (cAMP). Other potent compounds are 9-deoxyforskolin (1), 1,9-dideoxyforskolin (2), forskolin I (7), forskolin J (8), forskolin L (9), isoforskolin (16), 1-acetylforskolin (17), forskoditerpenoside A (19), forskoditerpenoside B (20), coleol (21), coleosol (22), 3-hydroxyforskolin (25) etc. Besides well established food and traditional use, clinical evidence indicates its safety assessment and can be taken without any toxic effect. This review covers up to date ethnopharmacological, phytochemical and phytomedical information of C. forskohlii approaching towards its safety and therapeutic perspective.