Intracellular Antibody Immunity

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• 作者：Ruth E. Watkinson (1)
  William A. McEwan (1)
  Leo C. James (1)
  
  1. Protein and Nucleic Acid Chemistry Division ; Medical Research Council Laboratory of Molecular Biology ; Francis Crick Avenue ; Cambridge ; CB2 0QH ; UK
  
• 关键词：TRIM21 ; neutralization ; antiviral
• 刊名：Journal of Clinical Immunology
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：34
• 期：1-supp
• 页码：30-34
• 全文大小：417 KB
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  8. Mallery, DL, McEwan, WA, Bidgood, SR, Towers, GJ, Johnson, CM, James, LC (2010) Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proc Natl Acad Sci U S A 107: pp. 19985-90 CrossRef
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  11. McEwan, WA, Mallery, DL, Rhodes, DA, Trowsdale, J, James, LC (2011) Intracellular antibody-mediated immunity and the role of TRIM21. Bioessays News Rev Mol Cell Dev Biol 33: pp. 803-9 CrossRef
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  15. Keeble, AH, Khan, Z, Forster, A, James, LC (2008) TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved. Proc Natl Acad Sci U S A 105: pp. 6045-50 CrossRef
  16. Hauler, F, Mallery, DL, McEwan, WA, Bidgood, SR, James, LC (2012) AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. Proc Natl Acad Sci U S A 109: pp. 19733-8 CrossRef
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  18. McEwan, WA, Tam, JC, Watkinson, RE, Bidgood, SR, Mallery, DL, James, LC (2013) Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nat Immunol 14: pp. 327-36 CrossRef
  19. Vaysburd, M, Watkinson, RE, Cooper, H, Reed, M, O鈥機onnell, K, Smith, J (2013) Intracellular antibody receptor TRIM21 prevents fatal viral infection. Proc Natl Acad Sci U S A 110: pp. 12397-401 CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Infectious Diseases
  Internal Medicine
  Medical Microbiology
  
• 出版者：Springer Netherlands
• ISSN：1573-2592

文摘

Antibodies allow the immune system to target pathogens despite their tremendous diversity and rapid evolution. Once bound to a pathogen, antibodies induce a broad range of effector mechanisms, including phagocytosis and complement. However, these mechanisms are all initiated in the extracellular space, meaning that pathogens like viruses evade them upon infection of their target cells. Recently, it has been shown that, in addition to mediating extracellular immune responses, antibodies also activate immunity inside infected cells. Antibodies that are bound to the surface of non-enveloped viruses or bacteria are carried into the cell during pathogen entry. Once inside the cell, these pathogen-attached antibodies are recognised by a highly conserved, high affinity cytosolic antibody receptor called TRIM21. TRIM21 initiates both sensor and effector responses that reduce viral replication and induce an antiviral state. These responses are an important part of antiviral immunity and the removal of TRIM21 results in uncontrolled viraemia and death in a mouse model of infection.