Pharmacokinetics of temozolomide administered in combination with O⁶-benzylguanine in children and adolescents with refractory solid tumors

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• 作者：Holly J. Meany ; Katherine E. Warren ; Elizabeth Fox ; Diane E. Cole ; Alberta A. Aikin and Frank M. Balis
• 关键词：Temozolomide ; Pharmacokinetics ; Pediatric ; Solid tumors
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2009
• 出版时间：December, 2009
• 年：2009
• 卷：65
• 期：1
• 页码：137-142
• 全文大小：273.8 KB

文摘

Purpose Temozolomide pharmacokinetics were evaluated in children receiving concurrent O6-benzylguanine (O6BG), which enhanced the hematological toxicity of temozolomide.