Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates

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• 作者：Shana Jacobs ; Cynthia L. McCully ; Robert F. Murphy ; John Bacher ; Frank M. Balis and Elizabeth Fox
• 关键词：Platinum analogs ; CNS penetration ; Microdialysis
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2010
• 出版时间：April, 2010
• 年：2010
• 卷：65
• 期：5
• 页码：817-824
• 全文大小：257.1 KB

文摘

Purpose Cisplatin, carboplatin, and oxaliplatin are chemically reactive anticancer drugs with modest activity in brain tumors. Previously, we have demonstrated that drug exposure in cerebrospinal fluid (CSF) for these platinum analogs is <5 % of the plasma ultrafiltrate (UF) drug exposure in nonhuman primates. Microdialysis is a minimally invasive in vivo method for sampling small molecules in the blood and tissue extracellular fluid (ECF). The purpose of this study was to estimate the penetration of platinum analogs into the brain ECF.