Plasma and cerebrospinal fluid pharmacokinetics of intravenously administered ABT-751 in non-human primates

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• 作者：Steve Y. Cho ; Elizabeth Fox ; Cynthia McCully ; Joy Bauch ; Kennan Marsh and Frank M. Balis
• 关键词：ABT ; 751 ; Cerebrospinal fluid ; Non ; human primate ; Pharmacokinetics ; Tubulin ; Microtubule
• 刊名：Cancer Chemotherapy and Pharmacology
• 出版年：2007
• 出版时间：September, 2007
• 年：2007
• 卷：60
• 期：4
• 页码：563-567
• 全文大小：257 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Pharmacology and Toxicology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0843

文摘

Purpose ABT-751 is an orally bioavailable sulfonamide that binds to the colchicine binding site on β-tubulin and inhibits microtubule polymerization. The plasma and cerebrospinal fluid (CSF) pharmacokinetics of ABT-751, after a short intravenous infusion, were evaluated in a non-human primate (Macaca mulatta) model that is highly predictive of the CSF penetration of drugs in humans.